Spinal Cord Diseases, Spinal Cord Injuries
Conditions
Brief summary
The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1,2). In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete cervical level SCI and investigate its effectiveness for lower extremity rehabilitation.
Interventions
DEVICEPaired associative stimulation (with eXimia magnetic stimulator and Dantec Keypoint® electroneuromyography device)
Paired associative stimulation (PAS) administered several times per week for 8 weeks to lower limbs. PAS comprises transcranial magnetic stimulation (eXimia magnetic stimulator, Nexstim Ltd, Helsinki, Finland) and peripheral nerve stimulation (given with Dantec Keypoint® electroneuromyography device (Natus Medical Incorporated, Pleasanton, CA, USA)).
Sponsors
Validia Rehabilitation Centre
Helsinki University Central Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* cervical incomplete SCI
Exclusion criteria
* epilepsy * metal inclusion in the head area * pacemaker * hearing device * high intracranial pressure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Daniels and Worthingham's Muscle Testing | 2 days after the last stimulation session | Leg muscle stenght is evaluated on 0-5 scale (0=no movement, 5=normal) |
Countries
Finland
Outcome results
None listed