Primary Antiphospholipid Syndrome
Conditions
Keywords
Antiphospholipid Syndrome - Bad obstetric history - Ocular
Brief summary
Antiphospholipid antibody syndrome (APS) is an autoimmune disease characterized by systemic thrombosis and bad obstetric history. APS secondary to another medical disorder is the most common. Visual and ocular changes e.g. vaso-occlusive disease of retinal and choroidal vessels are found in patients with secondary APS. Patients with primary APS have also been reported to have ocular changes e.g. retinal vascular occlusion The aim of our study to detect prevalence of ocular changes in women diagnosed with primary APS and correlation of these changes with adverse obstetric outcome. If a correlation is present, ocular findings in women with APS could be used in the future as a predictor for poor obstetric outcome.
Interventions
DIAGNOSTIC_TESTOphthalmological examination
Detailed anterior segment examination using slit-lamp biomicroscopy for signs of anterior uveitis, and detailed fundus examination using slit-lamp fundus biomicroscopy with + 90 diopter lens searching for signs of vasculitis and posterior uveitis.
Sponsors
Cairo University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Age: 18 to 35 years * Females with primary antiphospholipid syndrome
Exclusion criteria
* Age: below 18 years and above 35 years * Auto-immune diseases e.g. SLE and other connective tissue disease * Medical diseases causing retinal vascular changes e.g. hypertension, diabetes mellitus, sickle cell anemia. * Previous vitreo-retinal surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of Ocular changes in females with antiphospholipid syndrome | On the same day of enrollment into the study | Number of participants with ocular findings detected by ophthalmological examination |
Countries
Egypt
Outcome results
None listed