Peripheral Arterial Disease
Conditions
Keywords
Peripheral Arterial Disease, Exercise capacity, Physical activity, Respiratory muscle strength, Peripheric muscle strength
Brief summary
The primary aim of the study is to evaluate the maximal and submaximal exercise capacity in patients with peripheral artery disease (PAD). The secondary aim of the study is assessment of physical activity level, respiratory function, peripheral and respiratory muscle strength, respiratory muscle endurance, depression, quality of life, intermittent claudication and cardiovascular risk factors in patients with PAD.
Detailed description
Peripheral artery disease is characterized by reduced exercise capacity, physical activity level and intermittent claudication. The number of studies investigating maximal and submaximal exercise capacity and physical activity level in PAD is limited. There is also no study investigated pulmonary functions, respiratory muscle strength and endurance in this patient population. According to the sample size analysis 15 patients and 15 healthy individuals with similar demographic characteristics will be included the study. Patients and healthy individuals will be selected according to predetermined inclusion and exclusion criteria. The assessments will be completed in two days.Maximal exercise capacity will be assessed using cardiopulmonary exercise testing (CPET), functional exercise capacity using six minute stepper test, physical activity using multi-sensor activity monitor, pulmonary function using spirometry, respiratory muscle strength using mouth pressure device, peripheral muscle strength using hand held dynamometer, respiratory muscle endurance using incremental threshold loading test, depression using Beck depression inventory (Turkish version), life quality using SF-36 Health Survey (Turkish version), intermittent claudication using Walking Impairment Questionnaire (Turkish version)
Interventions
None listed
Sponsors
Gazi University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Patients; * Diagnosed with peripheral artery disease * Ankle brachial index (ABI)≤ 1,5 or calcified vessel response * Clinically stable and under standard medication patients will be included
Exclusion criteria
Patients with; * Ischemic amputation * Any pulmonary disease * Unstable coronary artery disease * Orthopedic and neurological problems * Acute infection * Myocardial infarction or major surgery in the last 3 months will be excluded Healthy controls: Ages 18-80 years will be included * With any diagnosed disease and smoking more than 10 packsyears will be excluded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal exercise capacity | First day | Cardiopulmonary exercise testing (Oxygen consumption measurement during test) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physical activity | Second day | Multi sensor activity monitor |
| Pulmonary function | First day | Spirometry |
| Respiratory muscle strength | First day | Mouth pressure device |
| Peripheral muscle strength | Second day | Hand held dynamometer |
| Functional exercise capacity | Second day | Six minute stepper test |
| Depression | Second day | Beck depression inventory (Turkish version) |
| Life quality | Second day | SF-36 Health Survey (Turkish version) |
| Intermittent claudication | Second day | Walking Impairment Questionnaire (Turkish version) |
| Respiratory muscle endurance | Second day | Incremental threshold loading test |
Countries
Turkey (Türkiye)
Outcome results
None listed