Metabolic Syndrome, Overweight and Obesity
Conditions
Keywords
Pituitary, Obesity, Overweight, Metabolic syndrome, MRI
Brief summary
This study aims to identify new morphological and quantitative magnetic imaging parameters of pituitary gland and sellar region in overweight and obese patient at baseline and after 3 years, dividing patients in 3 groups (weight loss through diet and lifestyle changes, weight loss through bariatric surgery, no weight loss)
Detailed description
This longitudinal prospective study in overweight and obese patients aims to identify and characterize new morphological and quantitative MRI parameters of pituitary gland and sellar region assessed by texture analysis with a specific software (ImageJ©). These parameters will be correlated them to hypothalamic-pituitary-peripheral axis function, metabolism and body composition. Data will be detected at baseline and at 3 years follow-up to quantitatively identify the different pituitary MRI patterns in 3 groups: 1. patients without weight modifies 2. patients with weight loss obtain through diet and lifestyle changes 3. patients with weight loss obtained through bariatric surgery
Interventions
PROCEDUREBariatric surgery
BEHAVIORALDiet and lifestyle changes
Sponsors
University of Roma La Sapienza
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* BMI \> 25 Kg/m2
Exclusion criteria
* Malignant neoplasia; * Current use of psychotropic drugs; * Chronic renal failure; * Pituitary macroadenomas and craniopharyngiomas; * Contraindications to MRI execution (p. e. pace-maker, metal foreign bodies like slivers, non MRI compatible vascular clips or prosthesis)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pituitary volume | 0, +3 years | Change in pituitary volume (mm3) from baseline to 3 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of pituitary mean and standard deviation intensity | 0, +3 years | Changes in new quantitative magnetic imaging parameters of pituitary gland from baseline to 3 years |
| Correlation of magnetic resonance parameters with anthropometric measurements | 0, +3 years | Correlation analysis of pituitary mean and standard deviation intensity with anthropometric measurements |
| Correlation of magnetic resonance parameters with pituitary axis function | 0, +3 years | Correlation analysis of pituitary mean and standard deviation intensity with pituitary axis function |
| Correlation of magnetic resonance parameters with glyco-metabolic status | 0, +3 years | Correlation analysis of pituitary mean and standard deviation intensity with glyco-metabolic status |
Countries
Italy
Outcome results
None listed