Evaluation of Lung Atelectasis During Apneic Oxygenation Using THRIVE in Adults During Laryngeal Surgery.

Evaluation of Lung Atelectasis During Apneic Oxygenation Using Trans Nasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) in Adults During Laryngeal Surgery.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03458091

Acronym

A-THRIVE

Enrollment

Registered

2018-03-08

Start date

2018-01-22

Completion date

2020-10-10

Last updated

2020-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Brief summary

Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing. The THRIVE technique is able to oxygenate patients safely and vital parameters has been shown to be stable. But it is of great importance to evaluate this new concept regarding other potential negative physiological aspects such as lung atelectasis and inflammatory stress response before implementing it into clinical practice.

Interventions

DEVICETHRIVE

Oxygenation during apnea using transversal humidified oxygen

DEVICEEndotracheal intubation

Ventilation during the procedure is governed by an endotracheal tube in the trachea and mechanical ventilation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Adults, \>18 years old. 2. ENT-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery). 3. Capable of understanding the study information and sign the written consent.

Exclusion criteria

1. ASA\>2 2. NYHA \>2 3. Pacemaker or ICD. 4. BMI \>35 5. Pregnancy 6. Manifest cardiac failure or coronary disease 7. Severe gastrointestinal reflux. 8. Neuromuscular disorder

Design outcomes

Primary

Measure	Time frame	Description
Electrical impedans tomography	baseline, intraoperative, 2 hours after start of intervention	Changes in lung volumes

Secondary

Measure	Time frame	Description
Difference in Endtidal and arterial carbon dioxide partial pressure in the end of the procedure	max 30 minutes after start of intervention	Difference in Endtidal and arterial carbon dioxide partial pressure in the end of the procedure
Increase in arterial carbon dioxide during the apnea	max 30 minutes after start of intervention	Measurement of arterial blood gases and here arterial carbon dioxide

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026