Saliva Profiles in Children With Congenital Heart Disease

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03457974

Enrollment

Registered

2018-03-08

Start date

2011-01-01

Completion date

2012-01-01

Last updated

2018-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Disease, Dental Caries

Keywords

saliva composition, antioxidant activity, caries risk factors, congenital cardiac disease

Brief summary

The purpose of this study was to evaluate whether there are relationships between the salivary oxidative stress status of children with CHD directly dental caries including gender, age, salivary flow rate, salivary pH, salivary buffering capacity and drug intake such as angiotensin-converting enzyme (ACE) inhibitors. If such relationships exist, they might be employed to patient caries -prevention treatment.

Detailed description

Using heart failure medications may cause low salivary pH and buffering capacity.As improved oral health is a priority for cardiac patients, it is necessary that they attend dental clinics for regular follow up. This cross sectional study was carried out with 42 CHD and 42 healthy children who applied to Istanbul University, Faculty of Dentistry, Department of Pedodontics. Gender, age, general health and medications, and caries scores (dfs/DMFS) were recorded. Unstimulated saliva was collected from the participants and were assessed for the salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.

Interventions

OTHERsaliva

salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Subject)

Intervention model description

cross sectional study was carried out with 42 CHD and 42 healthy children

Eligibility

Sex/Gender

ALL

Age

3 Years to 12 Years

Healthy volunteers

Yes

Inclusion criteria

* 3-12 years * Caridac problems

Exclusion criteria

* other ages * syndromes * other systemic diseases

Design outcomes

Primary

Measure	Time frame	Description
salivary buffering capacity	2 hour	salivary buffering capacity
salivary secretion rate	2 hour	salivary secretion rate
pH	2 hour	pH

Secondary

Measure	Time frame	Description
the thiobarbituric acid reactive substances (TBARS)	2 hour	the thiobarbituric acid reactive substances (TBARS)
ferric reducing antioxidant power (FRAP)	2 hour	ferric reducing antioxidant power (FRAP)
protein levels of saliva	2 hour	protein levels
superoxide dismutase (SOD)	2 hour	superoxide dismutase (SOD)

Other

Measure	Time frame	Description
protein carbonyl	2 hour	protein carbonyl
total sialic acid	2 hour	total sialic acid
protein thiols	2 hour	protein thiols

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026