Status Epilepticus
Conditions
Brief summary
Convulsive and Non Convulsive Status Epilepticus (SE) and Pseudo Status Epilepticus prospective registry. Data collection using a standardized form : demographic data and data related to the SE, including circumstances of onset, dates and times of onset and of seizure control, on-scene clinical findings, clinical features of the seizures, pre-hospital and hospital care providers, timing of antiepileptic and supportive treatments, results of etiological investigations, cause of SE, type and dosage of antiepileptic drugs. Dates and times of EEG monitoring, EEG results. Outcomes including vital status and Glasgow Outcome Scale score at ICU and hospital discharge, day-90 and 1-year after SE and determined based on data in the ICU and/or neurologist charts and/or patients phone interview.
Interventions
None listed
Sponsors
Versailles Hospital
Ictal Group
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* SE defined as 5 min or more of (i) continuous clinical and/or electrographic seizure activity or (ii) recurrent seizure activity without recovery (returning to baseline) between seizures. * age \>= 18 years
Exclusion criteria
* age \< 18 years * postanoxic status epilepticus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Favorable outcome | 1 year | A favorable outcome is defined by a Glasgow Outcome Scale (GOS) of 5. The Glasgow Outcome Scale (GOS) will be determined according to patients charts review and/or general practitioner interview conducted by an independent assessor. The GOS score : \[1: Death, 2: Persistent vegetative state, 3: Severe disability, 4: Moderate disability, 5 : Low disability\] |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional impairment | 3 months, and 1-year, 5-years and 10-years | Percentages of the patients that experience functional impairment (motor, sensitive, cognitive, epilepsy) |
| total seizure duration | 72 hours | total seizure duration in minutes |
| percentages of the patients that experience recurrent convulsive and/or non-convulsive seizures within 12 hours after ICU admission | 12 hours | — |
| Favorable outcome | 3 months, 5-years and 10 years | A favorable outcome is defined by a Glasgow Outcome Scale (GOS) of 5. The Glasgow Outcome Scale (GOS) will be determined patients charts review and/or general practitioner interview conducted by an independent assessor. The GOS score : \[1: Death, 2: Persistent vegetative state, 3: Severe disability, 4: Moderate disability, 5 : Low disability\] |
| super refractory status epilepticus | 72 hours | — |
| total ICU and in-hospital length of stay | 90 days | total ICU and in-hospital length of stay in days |
| mortality rate | ICU and hospital discharge, 3-months, and 1-year, 5 years and 10 years | — |
| refractory status epilepticus | 24 hours | — |
Countries
France
Contacts
Primary Contactstephane LEGRIEL, MD
Outcome results
None listed