Laryngopharyngeal Reflux, Obstructive Sleep Apnea
Conditions
Brief summary
This study will investigate the changes in the reflux symptom index (RSI) and reflux finding score (RFS) among patients with obstructive sleep apnea after regular humidified CPAP therapy. Since these two diseases have strong associations then one may consider the possible benefits from therapy in between them.
Interventions
DEVICECPAP
Continuous positive airway pressure
Sponsors
Assiut University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients have to stop proton pump inhibitors (PPI) therapy 1 month before enrollment in the study. * To be eligible as LPR patients in our study, patients must have presented a RSI score \> 13 and a RFS score \> 7. These thresholds were highly correlated with pathological pH monitoring (pH \< 4)
Exclusion criteria
* Noncompliance for CPAP Use: According to the standard Medicare criteria to define CPAP compliance, the patients who demonstrated CPAP use ≥ 4 h/ night for ≥ 70% of the nights are considered compliant. * Antireflux therapy during the period of the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reflux symptom index (RSI) change | Change from the baseline RSI at 3 months of regular humidified CPAP application | Assessment of the changes in the reflux symptom index (RSI) among patients with obstructive sleep apnea according to the determined time frame |
| Reflux finding score (RFS) change | Change from the baseline RFS at 3 months of regular humidified CPAP application | Assessment of the changes in the reflux finding score (RFS) among patients with obstructive sleep apnea according to the determined time frame |
Outcome results
None listed