Factors Influencing Hemoglobin Variability and Its Association With Mortality in Hemodialysis Patients

Baskent University Nephrology Department

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03454906

Enrollment

169

Registered

2018-03-06

Start date

2009-01-31

Completion date

2010-02-28

Last updated

2018-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodialysis-Induced Symptom

Keywords

hemodialysis, hemoglobin variability, mortality, nutrition, inflammation

Brief summary

The aim of the study is to investigate the factors influencing hemoglobin variability with inflammatory and nutritional parameters and its associations with all-cause mortality among hemodialysis patients.

Detailed description

Fluctuation in hemoglobin levels that is known as hemoglobin variability during treatment with ESA is a well-documented phenomenon. Several factors have been found to affect hemoglobin variability, including drug related, such as pharmacokinetic parameters, patient-related differences in demographic characteristics and factors affecting clinical status, as well as clinical practice guidelines, treatment protocols and reimbursement policies. Inflammation is also an important factor associated with hemoglobin variability, and the consequences of persistent inflammatory activity are far-reaching in affected patients. In present study, the factors influencing hemoglobin variability with inflammatory and nutritional parameters and its associations with all-cause mortality among hemodialysis patients are investigated.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \>18 * on chronic hemodialysis treatment

Exclusion criteria

* All patients had a minimum of six hemoglobin measurements within a 6- month period, and they were excluded if they received a kidney transplant during this period or those who had blood transfusions during the baseline period. * Patients with serum ferritin\<100 μg/L were also excluded from the study because of reimbursement of our country.

Design outcomes

Primary

Measure	Time frame	Description
Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients	six month	investigation of factors influencing hemoglobin variability with inflammatory and nutritional parameters and the association of hemoglobin variability with all-cause mortality among hemodialysis patients

Outcome results