Cardiovascular Insufficiency
Conditions
Brief summary
The aim is to describe the physiological background for PLR and the interpretation of a PLR manoeuvre. The protocol entails the measurement of stroke volume (SV) at baseline (semirecumbent patient position), during PLR and after returning to semirecumbent position. Simultaneously blood pressure (BP), pulse rate (PR), pulse oximetric saturation (SpO2) and ECG are recorded. The procedure is performed in ten normal subjects, ten patients recruited in the cardiology outpatient department and ten critically ill patients under analgosedation in the ICU. Analysis includes changes in measured variables and heart rate variability in the frequency domain during the three phases of the experiment.
Detailed description
See above
Interventions
DIAGNOSTIC_TESTPassive Leg Raising
See above
Sponsors
Edwards Lifesciences
Region MidtJylland Denmark
Study design
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Consenting after written and oral information
Exclusion criteria
Contraindications to PLR: intracranial or abdominal hypertension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in cardiovascular variables I | 10 minutes | stroke volume, SV (mL) |
| Changes in cardiovascular variables II | 10 minutes | pulse rate, PR (min\^-1) |
| Changes in cardiovascular variables III | 10 minutes | blood pressure, BP (mmHg) |
| Changes in cardiovascular variables IV | 10 minutes | pulse oximetric saturation, SpO2 (%) |
| Changes in HRV frequency domain variables V | 10 minutes | Heart rate variability, HRV, variables in frequency domain (low frequency, LF, 0.04-0.15 Hz, high frequency, HF, 0.15-0.4 Hz) |
| Changes in HRV frequency domain variables VI | 10 minutes | HRV absolute power (ms\^2, natural logarithm transformed values of absolute powers of very low frequency, VLF, LF, and HF bands) |
| Changes in HRV frequency domain variables VII | 10 minutes | HRV relative power (absolute power/total power) |
| Changes in HRV frequency domain variables VIII | 10 minutes | HRV normalized power (%, normalized units, n.u.) |
| Changes in HRV frequency domain variables IX | 10 minutes | HRV total power given by VLF + HF + LF (ms2) and LF/HF ratio. |
Countries
Denmark
Outcome results
None listed