Functional Magnetic Resonance Imaging (fMRI) Exploration of Neurocognitive Processes Involved in Food Addiction (FA) in Obese Patients: Towards New Phenotypic Markers for an Optimized Care Pathway

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03454711

Acronym

AddictO

Enrollment

Registered

2018-03-06

Start date

2018-04-26

Completion date

2021-09-08

Last updated

2023-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

Obesity, Food addictions, Functional magnetic resonance imaging (fMRI), Metabolomics

Brief summary

Identification of the cerebral fMRI phenotype of obese patients with FA in cognitive task context based on food choice making

Detailed description

Obesity is a worldwide epidemic associated with many complications. The treatment of obesity is a failure if it does not take into account eating disorders. Among them, food addictions seem to be frequent among obese patients. Clinical diagnosis and therapeutic approaches depend on presence of these FA. Moreover, eating disorders are associated with visible brain abnormalities in fMRI but the cerebral fMRI phenotype of FA is not known.

Interventions

DEVICEfMRI

Brain MRI

DEVICEIndirect calorimetry

Resting energy expenditure

DEVICEBioimpedance

Measurement of body composition

BIOLOGICALLipid profile, glucose, HBA1c, metabolomic analysis

Blood sample

BEHAVIORALYFAS questionnaire, Binge Eating Scale, Hospital Anxiety and Depression (HAD) scale, hedonic evaluation test (liking)

Questionnaires to characterize eating habits and depression

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

30 Years to 50 Years

Healthy volunteers

Inclusion criteria

* female * right-handed * grade 1 and 2 obesity * aged between 20 and 50 * no other addictions including smoking * no contraindications to fMRI * affiliated to French Social Security * having given a written informed consent

Exclusion criteria

* abdominal circumference + upper limbs along the body \> 200cm * addiction to alcohol or other psychoactive substances * daily smoker * sleep Apnea Syndrome paired * psychotic psychiatric disorders * history of bariatric surgery * medical care in the nutrition unit * inability to comprehend or complete questionnaires * pregnant or breastfeeding woman * persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty.

Design outcomes

Primary

Measure	Time frame
Significant change in brain activity of the prefrontal cortex (area involved in the inhibitory control of food intake) measured by modification of BOLD (Blood-Oxygen-Level-Dependent) signal in fMRI during a cognitive task based on food choice making	Month 2

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026