Cardiovascular Risk Factor, Coronary Artery Disease
Conditions
Keywords
hypertension, high blood viscosity, hypercholesterolemia
Brief summary
This study will evaluate the effect of low level laser blood radiation applied to all participants for prevention of coronary artery disease in patients with high risk (hypertension,high blood viscosity, hypercholesterolemia as well as related immune issues)
Detailed description
The areas of low - intensity laser use have expanded in several conditions by different mechanisms and ways. Hypertension as one of coronary artery disease risk factors and early indicator of future cardiovascular events with high blood viscosity and elevated blood cholesterol levels with immune-pathological basis became necessary issue to be handled. Low Level Laser irradiation effects on blood is very essential way in revealing the mechanisms of the action of laser radiation on biological tissues by means of changes in metabolism, leading to molecular, cellular and systemic changes.
Interventions
DEVICElow level laser hemotherapy
semiconductor laser therapeutic instrument irradiate the circulating blood in the vessels of left hand acupoint and the mucosal tissue in the nasal cavity
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
55 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* stage I hypertensive patients * patients from 30 to 34.9 kg/m2 body mass index * medically stable patients * all participants have sufficient cognition enough to understand the requirements of the study
Exclusion criteria
* history of malignant disease * smoking * history of progressive fatal disease * history of drug or alcohol abuse * blood donation within at least 30 days * pregnant, trying to be pregnant or breast feeding * cognitive impairment that will make it difficult to partake in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes of blood pressure | 8 weeks | measuring blood pressure before and after each low level laser radiation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in IL-17 level | 45 days | measuring changes in IL-17 level before and after low level laser radiation session |
| change in functional capacity | 70 days | measuring of 6 minute walking test before and after low level laser irradiation as an indicator of functional capacity improving |
| change in CD 8 (cluster of differentiation 8) level | 45 days | measuring changes in CD 8 (cluster of differentiation 8) level before and after low level laser radiation session |
| changes in blood viscosity | 8 weeks | measuring changes in blood viscosity before and after low level laser radiation session |
| change in LDL (low density lipoprotien) level | 60 days | measuring changes in LDL (low density lipoprotien) level before and after low level laser radiation session |
| change in TG (triglyceride) level | 60 days | measuring changes in TG (triglyceride) level before and after low level laser radiation session |
| change in HDL (high density lipoprotien) level | 60 days | measuring changes in HDL (high density lipoprotien) level before and after low level laser radiation session |
| change in TC (total cholesterol) level | 60 days | measuring changes in TC (total cholesterol) level before and after low level laser radiation session |
Countries
Egypt
Outcome results
None listed