CT Portography in Grading of Liver Cirrhosis

Role of Multi Slice Computed Tomography Portography in Grading of Liver Cirrhosis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03453580

Enrollment

100

Registered

2018-03-05

Start date

2018-09-25

Completion date

2019-10-30

Last updated

2018-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CT Portography Grading of Liver Cirrhosis

Brief summary

Esophageal variceal bleeding and hepatic encephalopathy are serious complications of hepatic cirrhosis, and they may lead to high mortality rate and severely threaten life quality of the patients

Detailed description

The occurrence and development of Esophageal variceal bleeding and hepatic encephalopathy are closely related with portal vein system diseases, such as collateral circulation of portal hypertension and portal vein thrombosis. The prevention of Esophageal variceal bleeding and hepatic encephalopathy in hepatic cirrhosis has become a hot spot in clinical practice. Three-dimensional reconstruction of images obtained by multi-slice spiral computed tomography portography (MSCTP) is clear, realistic, and accurate. It can directly and quickly display all anatomical information of collateral portal vein system, and is recognized as a good method to display blood vessels

Interventions

RADIATIONmultislice computed tomography portography

imaging modality

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients with cirrhosis and\\or portal hypertension diagnosed by; laboratory or radiological parameters.

Exclusion criteria

* Patients with ligation, disconnection or shunting of esophageal varices. Patients with combined hepatic malignant tumor Patients with splenectomy. Patients with renal dysfunction or iodine allergy.

Design outcomes

Primary

Measure	Time frame	Description
Grading of liver cirrhosis	15 min	Grade I: i)level 4-5 by portal development will achieved in intrahepatic portal vein imaging; ii) collateral circulation mainly open at esophageal gastric fundus vein, or one branch of para-umbilical vein or esophageal peripheral vein was open; iii) hepatic artery-portal vein fistula or portal vein embolus was not formed. Grade II: i)level 3-4 by portal development will achieved in intrahepatic portal vein imaging; ii) in addition to opening of collateral circulation at esophageal gastric fundus vein, 2-3 branches of para-umbilical vein or esophageal peripheral vein open; iii) some hepatic artery-portal vein fistula or portal vein embolus not observed. Grade lll: level 2-3 by portal development are achieved in intrahepatic portal vein imaging; ii) esophageal gastric fundus vein, para-umbilical vein or esophageal peripheral vein all open, iii) hepatic artery-portal vein fistula or portal vein embolus is formed. Then we will do correlation with child -pugh score

Secondary

Measure	Time frame	Description
prediction of esophageal varices and hepatic encephalopathy	20 min	measuring diameters of main portal vein,left gastric, splenic, intra hepatic right and left portal vein.

Contacts

Primary ContactMostafa Hashem Mahmoud, professor

hashemradiol@yahoo.com01000684012

Backup ContactMarwa Mohamed Samy Mohamed, lecturer

marwasamy2014@gmail.com01025260404

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026