Exercise Effects on Sarco-Osteopenia in Older Men

Conditions

Osteopenia, Sarcopenia

Keywords

sarcopenia, osteopenia, older men, community dwelling, physical functioning

Brief summary

The study determined the effects of predominately resistance type exercise in combination with protein supplements on parameters of sarcopenia and osteopenia (sarco-osteopenia) in older, community dwelling men with sarcopenia and -osteopenia over 18 months.

K. J. Kircher, Oliver Chaudry, Armin M. Nagel, Mansour Ghasemikaram, Michael Uder et al. (9 authors)

BMC Geriatrics2024-02-087 citations

10.1186/s12877-024-04736-5

Effect of high-intensity resistance exercise on cardiometabolic health in older men with osteosarcopenia: the randomised controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)

Wolfgang Kemmler, Matthias Kohl, Simon von Stengel, Daniel Schoene

BMJ Open Sport & Exercise Medicine2020-12-0111 citations

10.1136/bmjsem-2020-000846

Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men-Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST).

Kemmler W, Kohl M, Fröhlich M, Schoene D, von Stengel S.

2020-11-2611 citations

10.1016/j.bone.2020.115772

Interventions

OTHERexercise

3x week predominately resistance exercise for 18 months

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Masking description

Outcome assessor are not aware of participant status and are nor allowed to ask correspondingly

Eligibility

Sex/Gender

MALE

Age

70 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Sarcopenia according to Baumgartner et al.(SMI: \> -2 SD\* T-Score) * Osteopenia at the lumbar spine or hip according to WHO (\> -1 SD T-Score) * community dwelling people * able to transfer to our lab

Exclusion criteria

* secondary osteoporosis * history of hip fracture * medication/diseases that relevantly affect muscle/bone metabolism (last 2 years) * alcohol abuses of more than 60 g/d ethanol * cardio-vascular diseases that prevent exercise * very low physical capacity that prevent exercise in a group setting SD: Standard Deviation

Design outcomes

Primary

Measure	Time frame	Description
Lumbar spine Bone Mineral Density (QCT)	changes from baseline to 18 months	Lumbar spine Bone Mineral Density as determined by Quantitative Computed Tomography

Secondary

Measure	Time frame	Description
Femoral Neck Bone Mineral Density	changes from baseline to 12 and 18 months	Total hip Bone Mineral Density as determined by dual-energy x-ray absorptiometry (DXA)
Skeletal muscle mass index	changes from baseline to 6, 12 and 18 months	Skeletal muscle mass as defined fat and bone free mass of the limbs as determined by DXA divided by square height
Gait velocity	changes from baseline to 6, 12 and 18 months	Habitual gait speed over 10 m
Lumbar spine Bone Mineral Density (DXA)	changes from baseline to 12 and 18 months	Lumbar spine Bone Mineral Density as determined by dual-energy x-ray absorptiometry (DXA)
Hip and leg extensor strength	changes from baseline to 6, 12 and 18 months	Maximum dynamic hip and leg extensor strength as determined by a isokinetic leg press
Muscle Density at the calf, thigh and para-vertebral site	changes from baseline to 6 and 12 months	Muscle Density at the calf, thigh and para-vertebral site as assessed by MRI
Hand-grip strength	changes from baseline to 6, 12 and 18 months	Maximum hand-grip strength of the dominant and non-dominant hand as assessed by a Jamar dynamometer

Countries

Germany

Outcome results

None listed