Anesthesia, Oxygen Toxicity
Conditions
Keywords
THRIVE
Brief summary
Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing. The THRIVE technique is able to oxygenate patients safely and vital parameters has been shown to be stable. But it is of great importance to evaluate this new concept regarding other potential negative physiological aspects such as biological stress response detected by blood-bourne biomarkers before implementing it into clinical practice.
Interventions
DEVICEApnoeic oxygenation using THRIVE
Apnoeic oxygenation using THRIVE
DEVICEEndotracheal intubation and mechanical ventilation
Endotracheal intubation and mechanical ventilation
Sponsors
Karolinska University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Adults, \>18 years old. 2. Laryngeal-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery). 3. Capable of understanding the study information and sign the written consent.
Exclusion criteria
1. American Society of Anaesthesiologist severity score \>2 2. New York Heart Association score \>2 3. Pacemaker or ICD. 4. Body Mass Index \>35 5. Pregnancy 6. Manifest cardiac failure or coronary disease 7. Severe gastrointestinal reflux. 8. Neuromuscular disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxidative stress | Up to 2 hours after start of intervention | Biomarkers of oxidative stress such as Thiobarbituric acid reactive substances, Advanced Oxidation Protein Products,Reactive oxygen species and total antioxidant capacity in blood samples |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Biomarkers of neuronal injury | Up to 2 hours after start of intervention | Biomarkers of neuronal injury and stress in blood such as S100 and Nuclear Serum Enolase |
| Biomarkers of cardiac damage | Up to 2 hours after start of intervention | Biomarkers of cardiac damage in blood such as troponin and ProBNP |
| Biomarkers of kidney injury | Up to 2 hours after start of intervention | Biomarkers of kidney injury in blood such as creatinine |
| Markers of RNA damage | Up to 2 hours after start of intervention | Markers of RNA damage in blood |
| Inflammatory response | Up to 2 hours after start of intervention | Biomarkers of Inflammatory response in blood such as cytokines and interleukins |
Countries
Sweden
Outcome results
None listed