Cortical Bone Erosion
Conditions
Keywords
Osteoporosis
Brief summary
The study of this study is to evaluate the age influence on cortical bone strength properties by two methods:HR-pQCT (HighResolution-peripheral quantitativeComputedTomography) and ultrasound. The main objective consists in the evaluation of the age influence on cortical thickness at 1/3 distal radius measured by US.
Detailed description
The study of this study is to evaluate the age influence on cortical bone by two methods: HR-pQCT and ultrasound. 84 patients will be measured. The cohort will be: * 21 women less than 70 * 21 women more than 70 * 21 men less than 70 * 21 men more than 70 Measurement will be performed at radius and at tibia (ultra-distal and distal). For all the sites one measurement will be performed by HR-pQCT to get reference values of thickness and BMDs. For the distal positions and additional measurement will be performed by an innovative ultrasound device that estimates cortical thickness and porosity. The participation to the study implies only a participation of one hour from the patient (30min for HR-pQCT measurements, 30 min for US). The main objectives consist in : * evaluating the age influence on cortical thickness at 1/3 distal radius measured by US * evaluating the age influence on cortical thickness at distal tibia measured by US * comparing porosities values measured by US to vBMD obtained by HR-pQCT * comparing cortical thickness values measured by HR-pQCT at 1/3 distal radius position to ultra-distal radus position and to the tibia * comparing vBMD values measured by HRpQCT at 1/3 distal radius position to ultra-distal radius position and to the tibia
Interventions
OTHERBone measurement by HR-pQCT and ultrasound
Measurement will be performed at radius and at tibia (ultra-distal and distal). For all the sites one measurement will be performed by HR-pQCT to get reference values of thickness and BMDs. For the distal positions and additional measurement will be performed by an innovative ultrasound device that estimates cortical thickness and porosity.
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* being 18 or older * coming from the rheumatology consultation at Lariboisière Hospital
Exclusion criteria
* BMI \> 28 * BMI \< 15 * cortisone treatment * recent fracture at non-dominant arm * wound on measuring zone * treatment interfering with bone architecture or bone density : oral of transdermic oestrogenes, bisphosphonates (Alendronate, Risedronate, Zoledronate) or Denosumab during the past 6 months-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cortical parameters measurement | Inclusion time | Cortical thickness at distal radius 1/3 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tibia parameters measurement by HR-pQCT | Inclusion time | Cortical thickness distal 1/2 tibia obtained by HR-pQCT * ultra-distal and 1/3 distal cortical thicknesses obtained by HR-pQCT * ultra-distal and 1/3 distal vBMD obtained by HR-pQCT |
| Porosity measurement | Inclusion time | Ultrasonic porosity obtained by HR-pQCT |
| vBMD measurement | Inclusion time | vBMD obtained by HR-pQCT |
| Tibia parameters measurement by US | Inclusion time | Cortical thickness distal 1/2 tibia obtained by US * ultra-distal and 1/3 distal cortical thicknesses obtained by HR-pQCT * ultra-distal and 1/3 distal vBMD obtained by HR-pQCT |
| Thicknesses measurement | Inclusion time | Ultra-distal thicknesses obtained by HR-pQCT |
| Ultra-distal vBMD measurement | Inclusion time | Ultra-distal vBMD and third distal obtained by HR-pQCT |
| Cortical parameters measurement | Inclusion time | 1/3 distal cortical thicknesses obtained by HR-pQCT |
Countries
France
Outcome results
None listed