Ankylosing Spondylitis, Arthritis, Psoriatic, Arthritis, Rheumatoid, Chronic Juvenile Arthritis
Conditions
Keywords
Chronic inflammatory rheumatism, Fertility, Procreation
Brief summary
Etiopathogenesis of Chronic inflammatory rheumatisms (CIR) includes genetic, autoimmune and environmental factors. Their impact on the quality of life is important, leading to a sometimes severe disability. Thus they are likely to affect female fertility through several mechanisms, including autoimmune since the association between immunity and fertility has already been demonstrated in other autoimmune diseases. This study wants to evaluate and compare the birth rate between CIR and control group.
Detailed description
Data collection will be carried out using a questionnaire submitted to women in charge of the rheumatology department of the University Hospital of Toulouse and having agreed to participate: * women with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis or Chronic juvenile arthritis for the chronic inflammatory rheumatism group * women with a mechanical rheumatic pathology for the control group The primary endpoint was birth rate after spontaneous or induced pregnancy in patients who attempted to procreate, in the CIR group and in the control group.
Interventions
Sending a questionnaire about fertility that will have to be returned to us in order to be included in the study. The questionnaires, anonymous, will be numbered according to their order of return.
Sponsors
University Hospital, Toulouse
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Patient with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis, Chronic juvenile arthritis, Chronic Inflammatory Rheumatism * Patient diagnosed before the age of 40 * Patient having given her no opposition to her participation in research * For the control group: patient not suffering from chronic inflammatory rheumatism, having consulted in Rheumatology for a mechanical pathology
Exclusion criteria
* Patient\> 40 years old at the time of diagnosis * Patient with insufficient medical data (treatments)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Birth rate after spontaneous or induced pregnancy | One day | Birth rate after spontaneous or induced pregnancy in women who have tried to procreate in the chronic inflammatory rheumatism group and in the control group. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Design time | One day | Design time in the CIR group and in the control group |
| Birth rate according to the treatments used | One day | Birth rate in the CIR group according to the treatments used |
| Rates of ectopic pregnancy, early or late spontaneous miscarriage | one day | Rates of ectopic pregnancy, early or late spontaneous miscarriage, early or late pregnancy, children born dead, preterm birth in the CIR group and in the control group |
| Rates of desire for pregnancy | One day | Rates of desire for pregnancy and study of the reasons for this lack of desire for pregnancy in the CIR group and in the control group |
| Rates of sexual dysfunction | One day | Rates of sexual dysfunction in the CIR group and in the control group |
| Birth rate according to the activity of the disease | One day | Birth rate in the CIR group according to the activity of the disease |
Countries
France
Contacts
Primary ContactJean Parinaud, MD
Backup ContactIsabelle Olivier, PhD
Outcome results
None listed