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The Effectiveness of Arthroscopic Cartilage Regeneration Facilitating Procedure for Patients With Knee Osteoarthritis

The Effect on Gait Pattern in Patients Receiving Arthroscopic Cartilage Regeneration Facilitating Procedure (ACRFP) for Treatment of Osteoarthritis

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03452423
Enrollment
100
Registered
2018-03-02
Start date
2017-05-30
Completion date
2018-12-31
Last updated
2018-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of Knees

Keywords

Osteoarthritis of knees, Arthroscopic cartilage regeneration facilitating procedure (ACRFP), Foot pressure, Gait

Brief summary

The aim of this study is to discuss the effect of gait pattern in patients receiving arthroscopic cartilage regeneration facilitating procedure (ACRFP) for treatment of osteoarthritis of knees.

Detailed description

Pain during gait is the most common and problematic symptom in individuals with osteoarthritis (OA) of knee joints. Limited range of motion, reduced walking speed, and a shortened stride length are also occasionally observed. These changes may be secondary or compensatory phenomena adopted by individuals to lessen the load on the OA-affected knees. It is generally agreed that medial plica can produce symptoms in the knee joint, and can be successfully treated by arthroscopic resection when it becomes inflamed, thickened, and fibrotic. In 2006, Lyu and Hsu reported that medial plica had strong correlation with medial compartment osteoarthritis of knees. In their further studies disclosing the kinematic relationship of the medial plica with the medial femoral condyle found that medial plica might cause some degree of abrasion on the surface of medial femoral condyle during knee motion. The repeated injuries elicited by this abrasion phenomenon might trigger some inflammatory process to gradually damage the cartilage of knee. Based on these findings, Lyu developed a concept of arthroscopic cartilage regeneration facilitating procedure (ACRFP) by arthroscopic resection of the medial plica, in addition to both medial and lateral capsular release, for the treatment of osteoarthritis of the knee joint. The clinical outcome of this procedure by eradication of the abrasion phenomenon caused by the tight, fibrotic, and hypertrophied medial plica, with decompression of the patellofemoral joint, the pain in most patients could be reduced, and the degenerative process in the medial compartment of some patients might be decelerated or arrested. During the ACRFP, additional procedures such as synovectomy, abrasiochondroplasty, or partial menisectomy may also be carried out when necessary. It has been found that the elimination of the existing detrimental factors may provide a preferable environment for regeneration of the damaged cartilage. Although the results of ACRFP for treatment of osteoarthritis of knee has been supported by several researches as being an effective method, it still lacks investigations on the gait pattern after such procedure. Therefore, the aim of this study is to discuss the effectiveness of the ACRFP for the patients with osteoarthritis of knee joints, specifically focused on their gait pattern.

Interventions

PROCEDUREACRFP

Arthroscopic cartilage regeneration facilitating procedure (ACRFP) is a set of surgical procedures that combines resection of medial plica, medial and lateral capsular release, synovectomy of focal synovitis, and chondroplasty of loosened cartilage flaps as a rationale for the deliberate arthroscopic management of osteoarthritic knee.

Sponsors

Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
20 Years to 85 Years
Healthy volunteers
No

Inclusion criteria

* Patients between the ages 20 and 85 who will receive ACRFP for treatment of osteoarthritis in the knee joints

Exclusion criteria

* Patients with walking disability

Design outcomes

Primary

MeasureTime frameDescription
Partial foot pressure as a percentage of body weightBefore intervention, at 3 months and 6 months after interventionach footprint during gait are divided into 6 areas, which are medial forefoot, medial midfoot, medial hindfoot, lateral forefoot, lateral midfoot, and lateral hindfoot. The average partial foot pressure in each area was then calculated in terms of the percentage of body weight.

Secondary

MeasureTime frameDescription
Partial foot area as a percentage of body mass index (BMI)Before surgery, at 3 months, and 6 months after interventionEach footprint during gait are divided into 6 areas, which are medial forefoot, medial midfoot, medial hindfoot, lateral forefoot, lateral midfoot, and lateral hindfoot. The average partial foot pressure in each area was then calculated in terms of the body mass index (BMI).
Gait CadenceBefore surgery, at 3 months, and 6 months after interventionThe number of steps per minute
Walking speedBefore surgery, at 3 months, and 6 months after interventionThe velocity of each single step
The Knee injury and Osteoarthritis Outcome Score (KOOS)Before surgery, at 3 months, and 6 months after interventionA questionnaire to assess the patient's subjective symptoms about their knee joints and associated problems caused by the disorders
Step lengthBefore surgery, at 3 months, and 6 months after interventionThe distance between the first point of contact of the foot with the ground and that of the contralateral foot
Step widthBefore surgery, at 3 months, and 6 months after interventionThe distance between the center of the heel contact and the following one, calculated perpendicularly to the direction of the horizontal axis drawn between the feet
Axis angleBefore surgery, at 3 months, and 6 months after interventionthe angle formed by the medial tangent of the foot and the line from the second/third toe to the center of the heel
Single leg stance timeBefore surgery, at 3 months, and 6 months after interventionThe length of time of each foot at the stance phase

Countries

Taiwan

Contacts

Primary ContactChuan-Hsin Yen, BS
Yanlisa0728@gmail.com+886933301155
Backup ContactShuo-Suei Hung, PhD
hung_ortho@yahoo.com.tw+886970333582

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026