Apraxia of Speech
Conditions
Keywords
Stroke
Brief summary
The purpose of this study is to determine whether the effect of treatment for acquired speech impairment can be enhanced by combining effective behavioral treatment with non-invasive brain stimulation. Transcranial direct current stimulation (tDCS), which delivers low-intensity current to the scalp, and is a safe and well-tolerated approach that poses a non-significant risk to participants. tDCS provides low intensity neural stimulation which has been shown to facilitate motor learning in other domains of stroke rehabilitation such as arm motor learning but the potential to enhance speech motor learning has not been explored. This will be examined with a series of single-case experimental designs.
Interventions
DEVICESoterix 1x1 line tDCS low-intensity stimulator
Introduction of the independent variable (treatment) across three different points in time. Participants will be randomly assigned to have each treatment phase begin after 3, 4, or 6 baseline sessions. This current stimulates the cortex, with anodal stimulation leading to a depolarized state in which neurons are more likely to fire.
DEVICESham
Patients will have two electrodes applied (one anode, one cathode) administering no stimulation
Sponsors
NYU Langone Health
National Institute on Deafness and Other Communication Disorders (NIDCD)
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Right-handed * Monolingual (English) * Single left-hemisphere CVA * A minimum of six months post-stroke * Clinical diagnosis of apraxia of speech * Normal speech perception * Passing score on the hearing screening.
Exclusion criteria
* Diagnosis of laryngeal voice disorder * Dysarthria * History of speech impairment prior to CVA * Presence of potential tDCS risk factors: damaged skin at site of stimulation; * Presence of electrically or magnetically activated implant (including pacemaker); * metal in any part of their body; * history of medication-resistant epilepsy in the family; * past history of seizures or unexplained spells of loss of consciousness.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in accuracy in recordings from tasks from baseline to post treatment | Baseline, 6 Months | Subjects will be given speech production tasks. Recordings of tasks will be scored for accuracy to measure speech motor learning |
Countries
United States
Contacts
CONTACTBuchwald Lab
PRINCIPAL_INVESTIGATORAdam Buchwald, MD
NYU Langone Health
Outcome results
None listed