Inferior Vena Cava Indexes in Positive Pressure Supports

Inferior Vena Cava Indexes (Collapsibility, Distensibility, Delta) in Positive Pressure Supports and Prediction Ability of Intravascular Volume Status in ICU Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03452046

Enrollment

100

Registered

2018-03-02

Start date

2016-09-01

Completion date

2018-03-15

Last updated

2018-04-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Positive-Pressure Respirations, Respiratory Failure

Keywords

Ultrasound,inferior vena cava, positive pressure

Brief summary

Collapsibility (CI-IVC), distensibility (dIVC) and delta (ΔIVC) indices, which are dynamic measures of inferior vena cava (IVC) diameter, are used to assess the intravascular volume status in critically ill patients. Positive pressure support (PS) has been shown to induce IVC diameter distention by increasing intrathoracic pressure, and high positive expiratory pressure (PEEP) decreases the CI-IVC percentage (4). During Triggered positive pressure support it is necessary to clarify which IVC index is valid for measuring the volume status.it is aimed to compare the IVC indexes (CI-IVC, DIVC, ΔIVC), positive rate of change with pressure, correlation with central venous pressure and accurate prediction of volume status in patients with different positive pressure support.

Detailed description

The IVC diameters at different pressure supports were measured by the same clinician after obtaining a clear image of where the US and IVC measurements were made and the probe stabilization was achieved. He performed the procedure of changing the pressure supports, a blind independent intensive care physician without working, and recorded the applied pressure supports respectively. The different pressure supports applied are as follows: 1. PS 10 mmHg-PEEP 5 mmHg, 2. PS 0 mmHg- PEEP 5 mmHg 3. PS 10 mmHg- PEEP 0 mmHg. 4. T-tube (PS 0 mmHg-PEEP 0 mmHg)

Interventions

OTHERIVC diametres

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age\>18 years * Current use of mechanical ventilation through an endotracheal tube.

Exclusion criteria

* Profound Hypoxia defined as a fraction of inspired oxygen requirement \>90% or a PEEP \>10 mmHg * Patient-ventilator desynchrony or active agitation * Unstable O2 requirement * Cardiovascular instability * Current PEEP requirements of \>10 mmHg * Current oxygen saturation (SpO2) of \<88%. * High intra abdominal pressure * Right cardiac failure * Morbid obesity

Design outcomes

Primary

Measure	Time frame	Description
Determine the effect of positive pressure on IVC collapsibility index	12 month	Determine the effect on CI-IVC of an increase in positive end-expiratory pressure and pressure support
Determine the effect of positive pressure on IVC distensibility index	12 month	Determine the effect on distensibility index of an increase in positive end-expiratory pressure and pressure support
Determine the effect of positive pressure on IVC delta index	12 month	Determine the effect on delta index of an increase in positive end-expiratory pressure and pressure support

Secondary

Measure	Time frame	Description
Determine the effect of positive pressure on central venous pressure	12 month	Determine the effect on central venous pressure of an increase in positive end-expiratory pressure and pressure support

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026