Exploratory Study of Volatile Organic Compounds in Alveolar Breath

Retrospective Analysis of Volatile Organic Compounds in Alveolar Breath as Biomarkers of Idiopathic Malodor

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03451994

Acronym

VOCs

Enrollment

Registered

2018-03-02

Start date

2011-10-01

Completion date

2020-10-11

Last updated

2020-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional and Metabolic Diseases

Brief summary

The purpose of this secondary analysis is to identify breath signatures associated with idiopathic malodor conditions.

Detailed description

Individuals with metabolic disorders may sporadically produce malodors despite good hygiene. Analysis of volatile organic compounds (VOCs) helps to gain insights into medical conditions arising due to metabolic dysfunction as different metabolic pathways emit and or consume various VOCs. These VOCs can be detected via the exhaled breath collected and analyzed with a portable breath collection apparatus. VOC profiles will be compared with self-reported symptoms and other observations of participating subjects.

Interventions

OTHERBreath test

Breath samples taken from all participants, analyzed with gas chromatography mass spectrometry (GC/MS), no treatment given.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* good general health * willing and able to travel to one of the participating sites

Exclusion criteria

* medical conditions that, in the opinion of the investigator, would prevent participation * elect not to participate in the study

Design outcomes

Primary

Measure	Time frame	Description
VOCs detected	2 years	Expired air sample drawn principally from alveolar breath is analyzed by gas chromatography-mass spectrometry. Chromatograms are searched against the NIST library. The response for each analyte is normalized by using internal standards containing 1-bromo-4-fluoro-benzene.

Secondary

Measure	Time frame	Description
Correlations between breath biomarkers and self-reported observations (questionnaires)	1 year	VOC profiles will be compared with self-reported symptoms, observed exposures and other observations of participating subjects. Volatile organic compounds differentiating the disease activity will be identified.

Countries

United Kingdom, United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026