Gene Mutations, High Myopia
Conditions
Keywords
High myopia, TGFB1Gene Polymorphisms, LAMA1 Gene Polymorphisms
Brief summary
The investigators aimed to investigate TGFB1 and LAMA1 gene polymorphisms in children with high myopia in order to determine the genetic basis of large myopic shifts causing severe visual impairment and complications. Seventy-four children with high myopia (≥6 diopters \[D\]; study group) and 77 emmetropic children (±0.5D; control group) were included. Genetic and polymorphism analyses were performed in the Medical Genetics Laboratory using DNA purified from the patients' blood samples.
Interventions
GENETICTGFB1 AND LAMA1 GENE POLYMORPHISMS
we evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with ≥6 D myopia in an attempt to further elucidate the genetic basis of high myopia.
Sponsors
Ege University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SCREENING
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
3 Years to 13 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients under the age of 13 * Patients with cycloplegic refraction values ≥6 D (for study group) * Emmetropic patients (for control group)
Exclusion criteria
* Patients who had additional ocular pathology that may affect refraction (such as glaucoma, cataracts, corneal disease) * Patients with history of ocular surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genetic basis of high myopia | 4 years | evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with ≥6 D myopia |
Outcome results
None listed