Hypertension
Conditions
Keywords
hypertension, female
Brief summary
The incidence of CVD-related deaths is generally higher in women than men. Postmenopausal changes in estrogen/androgen ratio that induce a relative androgen excess have been proposed as important factors in the higher prevalence of hypertension. Therefore, the investigators hypothesize that testosterone has potential role between hypertension and target organ damage in postmenopausal hypertensive women. And the objective is to evaluate the effects of testosterone between hypertension and target organ damage in postmenopausal hypertensive women.
Interventions
None listed
Sponsors
LanZhou University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
45 Years to 65 Years
Inclusion criteria
* Clinical diagnosis of hypertension * Women are all postmenopausal * Men are matched with women.
Exclusion criteria
* Secondary hypertension * Coronary disease * Heart failure * Arterial fibrillation * Previous myocardial infarction * Previous stroke * Malignant disease * Kidney failure * Liver failure * Neoplastic disease * Severe neurological diseases * Severe metabolic or organic decompensation * Refuse to sign the informed consent form
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relative indexes of myocardial remodeling | Baseline | Cardiac structure (left ventricular mass index in grams for square meter) measurement. |
| Ambulatory blood pressure monitoring | Baseline | Non-invasive ambulatory blood pressure monitoring (ABPM) was performed for every enrolled patient with an ABPM equipment. |
| The level of testosterone (T) | Baseline | Blood samples used to analyze the levels of sexual hormones were collected between morning 8:00 and 9:00 after an overnight fast. Testosterone (T) units on nanogram per deciliter. |
Outcome results
None listed