Traumatic Brain Injury
Conditions
Keywords
Traumatic brain injury, eye tracking, EEG, cognition
Brief summary
Traumatic brain injury (TBI) is one of the most frequent injuries affecting service members. Unfortunately, current neurocognitive assessment tools are unable to reliably detect mild TBI more than a few days post- injury. Therefore, development of advanced systems for assessment and diagnosis of TBI are a top priority within Department of Defense. This project aims to evaluate a combined electroencephalography (EEG) and eye tracking system capable of assessing compromised cognitive function stemming from TBI, with the goal of enhancing operational readiness and aiding in diagnosis, improving health care and rehabilitation for affected military personnel.
Detailed description
This study (N=100) will be a correlational study to assess cognitive function in healthy controls, individuals with mild TBI, and individuals with moderate-to-severe TBI. In general, participants will provide demographic information, medical history, and details of their head injury. Participants will also complete a brief neuropsychological assessment to obtain an index of cognitive ability, along with the Fusion Test with eye tracking and linked EEG. MRI data may also be obtained.
Interventions
None listed
Sponsors
Uniformed Services University of the Health Sciences
The Defense and Veterans Brain Injury Center
United States Naval Medical Center, San Diego
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
All groups: * Ability to use dominant hand to complete cognitive and motor tasks * Fluent in English Mild TBI group: * History of mild TBI \> 3 months and \< 10 years prior to enrollment * Self-report of post-concussive symptoms Moderate-to-Severe TBI group: \- History of moderate or severe TBI \> 3 months and \< 10 years prior to enrollment
Exclusion criteria
Control group: History of possible or confirmed brain injury All groups: * History of a medical condition (other than brain injury) that would be expected to affect cognitive or motor abilities (e.g. muscular dystrophy, multiple sclerosis, or psychotic disorders such as schizophrenia) * Presence of neurological condition, such as brain tumor, brain infection, seizure, or stroke * Presence of visual impairment that is uncorrected by glasses or contacts (including color blindness) * Evidence of current suicidal or homicidal ideation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG | One study visit | Spectral features and event related responses collected from scalp measurements during performance of an eye movement and working memory task. |
| Eye Tracking | One study visit | Saccadic latencies measured in response to cognitive task including working memory demands. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neurobehavioral Symptom Inventory (NSI) | One study visit | Self-report measure of post-concussive symptoms |
| Trail Making Test | One study visit | Consists of Part A and B which depends on psychomotor speed, visual search abilities, and placing demands on working memory and cognitive flexibility |
| Symbol Search | One study visit | Wechsler Adult Intelligence Scale- Fourth Edition (WAIS-IV) Symbol Search measures information processing speed |
| Digit Span | One study visit | WAIS-IV Digit Span including Digit Span Forward, Digit Span Backward, and Digit Span Sequencing, which measures memory span. |
Countries
United States
Outcome results
None listed