Long Term Results of Amniotic Membrane Transplant in Bullous Keratopathy Patients

Amniotic Membrane Transplant in Symptomatic Bullous Keratopathy Patients: Confocal Microscopy & AS-OCT Long Term Results

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03450954

Enrollment

Registered

2018-03-01

Start date

2016-10-01

Completion date

2016-11-30

Last updated

2018-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bullous Keratopathy

Brief summary

A retrospective study including 22 patients who have undergone amniotic membrane transplant in our unit up till 2016. Confocal microscopy and anterior segment optical coherence tomography (ASOCT) were performed to assess the retention of amniotic membrane and to detect any corneal structural changes. Comparison was made with 5 controls who had bullous keratopathy awaiting endothelial keratoplasty.

Detailed description

This retrospective cohort study (CREC Ref No.: CRE-2013.687) was approved by the Joint Chinese University of Hong Kong-New Territories East Cluster Clinical Research Ethics Committee. All patients who had AMT done due to symptomatic bullous keratopathy at the Prince of Wales Hospital and Alice Ho Miu Ling Nethersole Hospital (from 1998 onwards till June 2016) were invited back for confocal microscopy and anterior segment optical coherence tomography (ASOCT) at the clinic by the principal investigator (GS) from October to November 2016.

Interventions

PROCEDUREAmniotic membrane transplant

Amniotic membrane graft was transplanted onto the bullous cornea by the inlay technique

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* All patients who have undergone amniotic membrane transplant in our cluster up till 2016. * Patients who have bullous keratopathy on conservative treatment such as lubricants, bandage contact lens

Exclusion criteria

* patients who refuse to participate in the study, have passed away or cannot return for the clinical assessment will be excluded.

Design outcomes

Primary

Measure	Time frame	Description
Amniotic membrane retention	from date of operation till 2016	Amniotic membrane retention in the cornea was assessed with confocal microscopy

Secondary

Measure	Time frame	Description
Pain	from date of operation till 2016	pain score (from 0-10, scale interval 1, 0 no pain, 10 most painful)reduction after amniotic membrane tranplant

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026