Thiamine as a Metabolic Resuscitator After Cardiac Arrest

Blood Lactate Over Time

Time frame: 24 hours

Population: Seventeen patients (six in the placebo arm and eleven in the thiamine arm) missing 24-hour lactate as they had expired by this timepoint.

Determined using the Kidney Disease Improving Global Outcomes (KDIGO) criteria for Stage 3 acute kidney injury/kidney failure.

Time frame: First 7 days following Arrest

Population: Three patients from the placebo arm and one from the thiamine arm were excluded from the renal failure analyses due to pre-arrest end-stage renal disease requiring dialyses.

S100 and NSE levels at various time points

Time frame: various time points over 7 days

Population: Biomarker assays not run in the laboratory at this time

Absolute Cellular Oxygen Consumption Rate: We use two measures to capture Oxygen Consumption Rate; the basal respiration and the maximal respiration.

Time frame: 0 hours and 24 hours.

Population: Two patients from the thiamine group had a thiamine value \>1200 and were excluded.

Creatinine over Time

Time frame: 72 hours

Population: Thirty-two patients (thirteen in the placebo arm and nineteen in the thiamine arm) missing 72-hour creatinine as they had expired prior to the 72-hour timepoint.

Count/Proportion of Patients Scoring a Favorable CPC, defined as a score of 1 or 2. Cerebral performance category scores range from 1-5. Lower scores mean better outcomes.

Time frame: will be assessed up to 30 and 90 days

Population: Two patients, both from placebo arm, did not have 30 day CPC scores available. Four patients, all from the placebo arm, did not have 90 day CPC scores available.

Global Oxygen Consumption over Time

Time frame: 48 hours

Population: Only 12 patients in the thiamine group and 18 patients in the placebo group had atleast 60 minutes of metabolic data in the first 48 hours after study drug administration

Absolute Blood Level of Lactate

Time frame: 72 hours

Population: Thirty-two patients (thirteen in the placebo arm and nineteen in the thiamine arm) missing 72-hour lactate as they had expired prior to the 72-hour timepoint.~In addition, two more patients in the placebo arm alive at 72 hours were missing 72-hour lactate due to health care provider request/patient refusal.~No imputation was done for this secondary outcome.

Mortality in the study assessed at three timepoints.

Time frame: will be assessed at hospital discharge and up to 30 and 90 days.

Population: For 90-day mortality, two patients from the placebo arm were not reachable for follow-up and thus are missing this information.

Absolute PDH Activity Value

Time frame: 72 hours

Population: Only 20 patients from the thiamine group and 16 patients from the placebo group were alive and had PDH activity available at 72 hours.

Absolute PDH Quantity. Please note that the measurement of Absolute PDH Quantity is done using a relative quantity assay, and that PDH is an enzyme and not a stable protein; therefore the units of measure cannot be provided in mg and are instead listed in mini OD unit/min/mg protein.

Time frame: 72 hours

Population: Only 20 patients from the thiamine group and 15 patients from the placebo group were alive and had PDH quantity available at 72 hours.

Absolute PDH specific activity value

Time frame: 72 hours

Population: Only 20 patients from the thiamine group and 15 patients from the placebo group were alive and had PDH specific activity available at 72 hours.

SOFA score over time. SOFA score: Sequential Organ Failure Assessment Score, ranges from 0-24, higher scores mean worse outcomes.

Time frame: over 72 hours

Population: 13 patients in the placebo arm and 19 patients in the thiamine arm missing 72-hour SOFA scores as they had expired by this timepoint.~3 additional patients in the placebo arm were alive at 72-hours but are still missing 72-hour SOFA scores because one or more component scores required to calculate the SOFA scores were missing.