Visceral Obesity
Conditions
Brief summary
Given the increasing prevalence of obesity, there is an urgent need to find better strategies to promote physical activity in the community. The present study will invite 70-year-olds with central (abdominal) obesity to participate in a 10-week aerobic exercise program. Participants will be randomly assigned to one of two equally large groups. The first group will complete the exercise program in instructor-led groups. The second group will complete the program at home with the help of an on-line video.
Detailed description
Central obesity means having a lot visceral fat, that is, fat located in the abdominal cavity. Visceral fat is a well-established risk factor for cardiovascular disease and all-cause mortality. Participants will be recruited from the Healthy Ageing Initiative (HAI), an ongoing population-based study that invites all 70-year-olds in Umeå, Sweden, to a health examination. The exercise program will focus is on station-based aerobic exercises and resistance exercises, predominantly with participants' own body weight as resistance. The program is progressive, starting at a moderate pace so that participants learn to perform the exercises properly. The intensity will be aimed at 60-80% of maximal exhaustion, and each exercise bout will last 60 seconds with 20 seconds of rest between bouts. The program was developed by seniors in the bachelor's program in exercise physiology at Umeå University, Sweden.
Interventions
OTHER10-week aerobic exercise program
An aerobic exercise program consisting of 45-60 minute sessions 3 times a week for 10 weeks.
Sponsors
Umeå University
Region Västerbotten
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
The Data Analyst will also be masked.
Eligibility
Sex/Gender
ALL
Age
70 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Participated in the Healthy Ageing Initiative (a population-based intervention study in Umeå, Sweden) * Visceral adipose tissue mass \>1 kg (women) or \>2 kg (men)
Exclusion criteria
* Physical disability that affects ability to perform the exercises * Heart failure or severe degenerative condition (e.g. malignant cancer or multiple sclerosis) * Myocardial infarction or stroke in the past year * Heart condition that can worsen with aerobic exercise (e.g. angina)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in visceral adipose tissue mass | 0, 10, 20, and 31 weeks | Mass (g) measured using Lunar iDXA with CoreScan application (GE Healthcare, Wauwatosa, WI, USA). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Body Mass Index (kg/m^2) | 0, 10, 20, and 31 weeks | — |
| Change in blood pressure (mmHg) | 0, 10, 20, and 31 weeks | Taken after 15 min of rest |
| Change in blood-lipid profile | 0, 10, 20, and 31 weeks | — |
| Change in fasting blood glucose | 0, 10, 20, and 31 weeks | Veinous blood samples taken after \> 4 h of fasting |
| Change in isometric muscle strength | 0, 10, 20, and 31 weeks | Measured in non-dominant hand with dynamometer (Jamar, Lafayette Instrument, USA). The better of two successive trials will be recorded. |
| Change in physical capacity | 0, 10, 20, and 31 weeks | Measured using Åstrands Submaximal Test, performed on an electrically braked ergometer bicycle |
| Change in body composition | 0, 10, 20, and 31 weeks | Mass (g) measured using Lunar iDXA with CoreScan application (GE Healthcare, Wauwatosa, WI, USA) |
| Change in health-related quality of life | 0, 10, 20, and 31 weeks | As measured by RAND-36 |
| Change in self-reported physical activity | 0, 10, 20, and 31 weeks | Assessed using IPAQ-SF |
| Change in Microbiota composition | 0, 10, 20, and 31 weeks | Fecal samples are taken and bacterial DNA is sequenced to determine bacterial composition |
| Change in dietary habits | 0, 10, 20, and 31 weeks | 85 item food frequency questionnaire |
| Change in concentration of inflammatory markers | 0, 10, 20, and 31 weeks | — |
| Change in resting metabolic rate | 0, 10, 20, and 31 weeks | As measured by indirect calorimetry |
Countries
Sweden
Outcome results
None listed