Non Elective Cesarean Section and Ketamine Analgesia
Conditions
Brief summary
This randomized double blind study will be conducted in pregnant woman planned for non elective cesarean section under spinal anesthesia. Ketamine group will receive intravenous 0.25 mg/kg and placebo group will receive same amount of normal saline after spinal anesthesia prior to skin incision. Postoperative outcomes measures are total opioid consumption and pain scores for 24 hrs.
Interventions
DRUGKetamine
the analgesic affects of ketamine will be compared between the experimental and placebo group.
DRUGPlacebo
the analgesic requirement will be calculated in placebo group.
Sponsors
B.P. Koirala Institute of Health Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* • All women at term(\>or =37 weeks of gestation) * Healthy * American Society of Anesthesiologists(ASA) class1 and 2 * Women undergoing non-elective caesarean section whose anesthetic plan is for spinal anesthesia with bupivacaine and fentanyl
Exclusion criteria
* • Women with American society of anesthesiologist physical status\>2 * Body mass index \>or =40 kg per square meter * Height \<150 cm * Any contraindication to the spinal anesthesia * History of substance abuse * History of hallucinations * Chronic opioid therapy * Chronic pain or on any pain medication currently * Patient with maternal complications,like cardiovascular disease pre-eclampsia,diabetes,multiple gestation,known fetal abnormality * Cases with severely compromised fetus where immediate administration of general anesthesia is required.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total opioid requirement postoperatively | 24 hrs | Total opioid required up to 24 postoperatively in ketamine and placebo group. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative numerator rating scores(NRS)up to 24 hrs . postoperative ) | 24 hrs | • Postoperative NRS Scores (on arrival to Post operative care unit), 2, 4, 6, 8, 12 and 24 h ).The NRS ranges from 0- 10 and 0 refers to no pain and 10 means extreme possible pain perceived. |
| Time to first perception of pain | 24 hrs | Time to first perception of pain |
| Incidence of side effects | 24 hrs | Incidence of post operative nausea and vomiting, shivering, sedation scores, side effects related to ketamine during the first 24h |
Countries
Nepal
Outcome results
None listed