Hypertension Pulmonary Secondary, Multidetector Computed Tomography, Pulmonary Embolism and Thrombosis
Conditions
Keywords
Multidetector Computed Tomography, Pulmonary Embolism, Hypertension Pulmonary Secondary
Brief summary
A comparative, observational, cross-sectional and prolective diagnostic test study, including patients that have had a right heart catheterization and were referred for a CT pulmonary angiography as part of their imaging workup protocol for pulmonary hypertension. Dual-energy computed tomography (DECT) pulmonary angiography was performed on each patient to obtain perfusion maps and do a quantitative analysis. Segments with and without perfusion defects according to significant differences in the quantitative values, were defined as compatible or not with chronic thromboembolism. To assess the accuracy of the method and evaluate its performance, these results were compared with the sole results from the right heart catheterization, known to be the gold standard diagnostic tool.
Detailed description
a comparative, observational, cross-sectional and prolective diagnostic test study is conducted, including consecutive patients from the pulmonary hypertension clinic at our institution, from March 2017 to October 2018. Patients that have had a right heart catheterization and were referred for a CT pulmonary angiography as part of their imaging workup protocol. (The minimum sample size calculated is 26 patients). DECT pulmonary angiography (256-slice and double-source CT scanner) was performed on each patient. Obtaining perfusion maps and doing a quantitative analysis by circular regions of interest (ROI) and iodine-related attenuation values (IRA) on each lung segment. Then, according to the finding in right heart catheterization, a comparison will be made between to groups: segments with and without perfusion defects, in order to find significant differences in the quantitative. To assess the accuracy of the method and evaluate its performance, these results were later compared with the sole results from the right heart catheterization. ROC curves were plotted to extract possible decision thresholds of the IRA values to classify perfusion as normal or deficient with this technique.
Interventions
None listed
Sponsors
Sergio Criales Vera
Mariana Díaz Zamudio
Nayeli Zayas Hernández
Eric Kimura Hayama
Regina De La Mora
Tomás Pulido Zamudio
Instituto Nacional de Cardiologia Ignacio Chavez
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients from the pulmonary hypertension clinic at our institution who have had right heart catheterization and were referred for a pulmonary CT angiography as part of their imaging workup protocol.
Exclusion criteria
* creatinine \> 1.5 mg/dL
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lung perfusion measured with Dual-Energy CT (DECT) in patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH) | cross-sectional (one measurement). The minimum sample size calculated is 26 patients, which with the amount of patients handled in the pulmonary hypertension clinic at our institution is expect to reach in 16 months or before through study completion | The objective is to evaluate lung perfusion quantification by DECT in patients with Chronic Thromboembolic Pulmonary Hypertension and compare findings with digital subtraction angiography with right heart catheterization |
Countries
Mexico
Contacts
Primary ContactCesar Cristancho Rojas, physician
Backup ContactTomas Pulido Zamudio, Doctor
Outcome results
None listed