Astigmatism in Keratoconus Patients

Comparison of Anterior and Posterior Corneal Astigmatism in Patients With Keratoconus and Controls

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03450213

Enrollment

100

Registered

2018-03-01

Start date

2019-10-01

Completion date

2021-10-01

Last updated

2018-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconus

Brief summary

Keratoconus is a bilateral (but usually asymmetrical) non-inflammatory progressive thinning process of the cornea. It manifests as characteristic cone-like ectasia of the cornea associated with irregular stromal thinning, resulting in a cone-like bulge , which causing irregular astigmatism and vision impairment.

Detailed description

Keratoconus is the most common form of corneal ectasia, with an incidence of 50-230 per 100,000 persons.Pentacam used diagnose & detect the progression in patients with keratoconus and also provide a detailed information about corneal tomography and topography. In the last few years, it has been shown that in healthy individuals the posterior corneal surface has not only a different amount of astigmatism but also a different alignment of the steep meridian. The aim of this research is to compare the amount and axis alignment of anterior and posterior corneal astigmatism in keratoconus with a healthy controlled group .

Interventions

DEVICEPentacam

Pentacam will be used to measure the magnitude and axis orientation of anterior and posterior corneal astigmatism.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Patients diagnosed with keratoconus using the following criteria: Specific diagnostic signs is asymmetric refractive errors with high progressive or irregular astigmatism, and elevated keratometry values, scissoring of the red reflex, Vogt striae, Fleischer rings, inferior or central steepening on topography with abnormal localized steepening .

Exclusion criteria

* Unwillingness to participate in the study . * Corneal scarring. * Any ectatic conditions that were not explicitly keratoconus such as keratoglobus and pellucid marginal degeneration . * Previous ocular surgery.

Design outcomes

Primary

Measure	Time frame	Description
Comparison between astigmatism in patients with keratoconus and normal people.	Two years	Pentacam will be used for comparison between astigmatism in patients with keratoconus and normal people at the same age and sex

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026