Postpartum Preeclampsia
Conditions
Brief summary
Hypertensive disorders of pregnancy are important cause of severe morbidity, long-term disability and death among both mothers and their babies. In Africa and Asia, nearly one tenth of all maternal deaths are associated with hypertensive disorders of pregnancy research has focused on the antenatal complications' for both mother and baby and the risks and benefits of administering antihypertensive therapy prior to delivery hypertension disorders of pregnancy often persist following delivery and sometimes arise de novo postpartum one of the maternal complications of pre eclampsia is residual chronic hypertension in about 1/3 of cases elevated blood pressure is seen in 6%to 8% of all pregnancies hypertension (arterial pressure \>140/90 mmhg) in pregnancy is classified into one of four conditions 1. chronic hypertension that precedes pregnancy 2. pre eclampsia and eclampsia: a systematic syndrome of elevated arterial pressure,proteinuria and other findings 3. pre eclampsia superimposed upon chronic hypertension 4. gestational hypertension or nonproteinuric hypertension of pregnancy
Detailed description
Hypertensive disorders of pregnancy are important cause of severe morbidity, long-term disability and death among both mothers and their babies. In Africa and Asia, nearly one tenth of all maternal deaths are associated with hypertensive disorders of pregnancy research has focused on the antenatal complications' for both mother and baby and the risks and benefits of administering antihypertensive therapy prior to delivery hypertension disorders of pregnancy often persist following delivery and sometimes arise de novo postpartum one of the maternal complications of pre eclampsia is residual chronic hypertension in about 1/3 of cases elevated blood pressure is seen in 6%to 8% of all pregnancies hypertension (arterial pressure \>140/90 mmhg) in pregnancy is classified into one of four conditions 1. chronic hypertension that precedes pregnancy 2. pre eclampsia and eclampsia: a systematic syndrome of elevated arterial pressure,proteinuria and other findings 3. pre eclampsia superimposed upon chronic hypertension 4. gestational hypertension or nonproteinuric hypertension of pregnancy evaluate the effectiveness, safety and acceptability of Oral nifedipine versus oral labetalol in treatment of persistent postpartum hypertension
Interventions
DRUGOral Tablet
oral labetalol tablets and oral nifedipine tablets
Sponsors
Assiut University
Hossam Ahmed Abd Ellah
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Women who have hypertension during pregnancy and persist after delivery till discharge of hospital about 2 days of monitoring the blood pressure
Exclusion criteria
Women with history of secondary hypertension Women with eclampsia who need intensive care unit admission and indicated other drugs rather than oral nifedipine and oral labetalol Women who have any contraindication to Nifedipine or labetalol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| control blood pressure | till discharge of hospital about two days | duration,total dose to achieve blood pressure below the critical value between 140 and 150 mmHg systolic and 90-100 mmHg diastolic by monitoring of blood pressure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resolution of complications | till discharge of hospital about two days | Measured by monitoring of blood pressure and monitoring of the complications |
| Improvement of hematological values | till discharge of hospital about two days | By repeated Complete blood count |
| Side effects in both groups | till discharge of hospital about two days | Monitoring if there is any side effect of any drug |
| Improvement of other investigations | till discharge of hospital about two days | Monitoring by repeated urine analysis,other investigations |
Countries
Egypt
Contacts
Primary ContactHossam Ahmed Abd Ellah, MBBCH
Outcome results
None listed