Pregnancy
Conditions
Keywords
periodontitis, postpartum
Brief summary
The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of IL-17A, IL-17E, IL-6 AND IL-23 during 2/3 trimester of pregnancy and after delivery.
Detailed description
IL-17 have a synergytic effect with IL-6 and IL-23. IL-17A levels elevated with periodontal diseases. Many systemical chronic conditions such as atherosclerosis and cardiovascular disease, pregnancy may contribute increasing of IL-17 family cytokine.
Interventions
OTHERSaliva collection
OTHERGCF collection
Sponsors
Aydin Adnan Menderes University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* women 2 and 3 trimester of their pregnancy
Exclusion criteria
* any known systemic disease, * periodontal treatment within the last six months, * patients having less than 10 teeth, * smokers, * individuals with a BMI \> 30 kg/m2, * gestational diabetes and preeclampsia during pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changing Il-17A levels | 6 month | Salivary and GCF level measured by ELISA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changing IL-6 levels | 6 month | Salivary and GCF level measured by ELISA |
| Changing IL-23 levels | 6 month | Salivary and GCF level measured by ELISA |
| Changing IL-17E levels | 6 month | Salivary and GCF level measured by ELISA |
Outcome results
None listed