Research on Association Between Selenium Deficiencies and Change of Thyroid Function

Effect of Selenium Deficiency on Thyroid Function

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03448588

Enrollment

200

Registered

2018-02-28

Start date

2018-04-01

Completion date

2019-04-01

Last updated

2018-05-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Selenium Deficiency

Brief summary

As one of the essential micronutrients, selenium has important biological functions. However, an effective and convenient method for evaluation of selenium nutritional status has not yet been established. Previous literature has disclosed effect of selenium deficiency on inactivating glutathion peroxidase and deiodinase, which may cause decreased conversion from thyroxine ( T4) to triiodothyronine (T3). A case-control study is designed to demonstrate the association between selenium deficiency and abnormally elevated T4 or T4/T3, which may provide more clues for establishing effective selenium assesment methods.

Interventions

DIAGNOSTIC_TESTdetection of serum selenium

For this case-control study, no intervention will be administered to participants, only serum sample will be collected for selenium assessment

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* with normal free triiodothyronine( FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH). * without thyroid hormone replacement therapy * without medical history of thyroid surgery * without iodine radiotherapy;

Exclusion criteria

* acute critical illness in the latest 1 year; * weight fluctuation by more than 5% in the latest 3 months; * eating disorders * neuropsychological disorders * allergy to corn or yeast * fail to give informed consents.

Design outcomes

Primary

Measure	Time frame	Description
between-group difference in serum selenium	up to 24 weeks	comparison of the mean serum selenium between the two groups

Secondary

Measure	Time frame	Description
between-group difference in serum deiodinase activity	up to 24 weeks	comparison of the mean deiodinase activity between the two groups
between-group difference in erythrocyte glutathione peroxidase activity	up to 24 weeks	comparison of the mean erythrocyte glutathione peroxidase activity between the two groups

Countries

China

Contacts

Primary ContactYanping Liu

liuyp1227@vip.sina.com+861069159088

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026