Postoperative Pain
Conditions
Keywords
brain stimulation, tDCS, acute postoperative pain, chronic pain
Brief summary
the role of transcranial magnetic stimulation over the primary motor cortex area on acute postoperative pain after breast cancer surgery and on the probability of developing chronic neuropathic pain.
Detailed description
New analgesic strategies are needed that can be used adjunctively to existing strategies with the potential to reduce reliance on opioid analgesia. Several novel brain stimulation technologies including transcranial direct current stimulation (tDCS) are beginning to demonstrate promise as treatments for a variety of pain conditions. Electricity has no metabolite or other residue, and can be delivered with minimal discomfort and without problems associated with drug-drug interactions.Transcranial direct current stimulation has been studied in patients with various disorders and multiple pain syndromes. There is also evidence that tDCS might be useful in postsurgical pain reduction.
Interventions
DEVICEtDCS
motor cortex stimulation (2 mA, 20 min for 4 sessions)
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-II, scheduled for unilateral modified radical mastectomy with axillary dissection for breast cancer
Exclusion criteria
* patients with intracranial metallic devices or with pacemakers or any other device. * patients with Neurological or psychiatric disorders, * patients taking major centrally acting drugs (antiepileptics or antidepressants), -opioid dependence, * substance abuse, * severe cardiopulmonary, renal, hepatic diseases, and * those with extensive myocardial ischemia or unstable angina.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| total morphine comsuption | 48 hours | the total dose of morphine used as analgesic expressed in mg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Visual analogue scale | baseline,at 2,4,6, 12, 24,36,48 hours | patient asked to describe this pain with scores ranging from 0 to10 (with 0 = no pain and 10 = the worst pain imaginable) |
| Douleur Neuropathique 4 questions DN4 | 1month, 3month, 6 month | the possibility of development of neuropathic pain will be assessed using DN4 scale |
Countries
Egypt
Outcome results
None listed