Colo-rectal Cancer
Conditions
Brief summary
Colorectal cancer is the third most commonly diagnosed cancer in the world. The 5-years survival rate depends on the tumor stage and grade at patient presentation. Individual treatment strategy based on the tumor stage and grade should be applied to improve the prognosis, So the pre-operative diagnostic evaluation and grading of colorectal cancer are important.
Detailed description
Diagnosis of cancer colon is usually based on colonoscopy which provides direct visualization of the lesions and allows for biopsies. However the pre-operative specimens from endoscopic biopsies sometimes fail to grade tumor because of the lack of sufficient tissue. Recent improvements in computed tomography have allowed for minimally invasive evaluation of cancer colon. Quantitative iodine density measurement can be used to differentiate low and high grade colorectal cancer. However, debate continues regarding the correlation between tumor grade and computed tomography perfusion parameters of colorectal cancer demonstrating the need for further investigation in this area of research.
Interventions
RADIATIONComputed tomography perfusion
Pre-contrast images will be obtained to identify the colorectal tumor location. Then Fifty milliliters of iopromide (Ultravist ) will be injected intra-venously at rate of 5 milliliter per second via an automatic pump injector for computed tomography perfusion scans. Computed tomography perfusion scans will be performed at the mid-portion of the tumor for 60seconds beginning 5 seconds after contrast injection. Then arterial input will be defined by using the mouse to place a circular region of interest and the tumor region of interest will be placed on the most enhanced area of the tumor. Tumor blood flow, blood volume, mean transient time & permeability surface measurements will be obtained.
Sponsors
Assiut University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Any patient with primary colorectal mass
Exclusion criteria
* Colorectal mass pathologically proved to be benign Female patient at child bearing period with suspected pregnancy Raised renal chemistry Hypersensitivity to contrast.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood flow of tumor | One month | Accuracy of blood flow of the tumor in prediction of tumor grade in correlation with histopathological results |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood volume of the tumor | One month | Accuracy of blood volume of the tumor in prediction of tumor grade in correlation with histopathological results |
| Mean transient time of the tumor | One month | transient time of the tumor in prediction of tumor grade in correlation with histopathological results |
| Permeability surface of the tumor | One month | Accuracy of permeability surface of the tumor in prediction of tumor grade in correlation with histopathological results |
Countries
Egypt
Contacts
Primary ContactAfaf A Hassan, MD
Backup ContactMostafa A El-Sharkawy, MD
Outcome results
None listed