Aphasia, Primary Progressive, Repetitive Transcranical Magnetic Stimulation
Conditions
Brief summary
The primary progressive aphasia (PPA) is a neurodegenerative condition characterized by a gradual, irreversible decline of language function (Mesulam, 2001). There are no known treatments for PPA so far. The relentless progression of PPA symptoms eventually leads to a profound impairment in communication ability and, ultimately, to more generalized deficits of cognition. Some cases and small studies reported that Transcranial Magnetic Stimulation (TMS), one of the non-invasive neuromodulation tech, can be employed to facilitate language production and improve the language ability in patients with PPA. Herein we will explore the tolerance and efficacy of TMS for the treatment of PPA by the randomized controlled trial .Meanwhile the functional MRI tech will be used to investigate the neural network changing in the procedure
Interventions
DEVICEMagstim rTMS
The device is made in London,UK
Sponsors
Peking Union Medical College Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
35 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
All participants had also been evaluated previously by a behavioral neurologist at the Peking Union Medical College Hospital and had been clinically diagnosed with a variant of PPA.
Exclusion criteria
1. Scored below 15 on the mini-mental state exam (MMSE) due to concerns that global cognitive impairment might preclude their ability to follow the directions and interfere with task performance. 2. Had a history of seizures or unexplained loss of consciousness, pregnancy, surgical breach of the skull, or any other medical or surgical contraindication to receiving noninvasive brain stimulation. 3. Is unable to complete the treatment and evaluations
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Boston naming test evaluation | Baseline | Assessment of the language production |
| Western Aphasia Battery(WAB) Speech fluency | Baseline | Assessment of the language production |
| Repetition Part of WAB | Baseline | Assessment of the repetition ability |
| Word recognition Part of WAB | Baseline | Assessment of the reading |
| Syntax comprehension Part of Bilingual Aphasia Battery( Standard modern Chinese version) | Baseline | Assessment of the grammar ability |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| fMRI parameters(strength, efficiency, clustering coefficient, and characteristic path length) | Baseline | Graph theoretical analysis of the speech/language network |
Outcome results
None listed