Alcohol Use Disorder
Conditions
Brief summary
The goal of this study is to compare \[C-11\]NOP-1A binding in recently abstinent alcohol use disorders and controls
Detailed description
This will allow for understanding brain stress and antistress mechanisms that underlie abuse of alcohol in humans
Sponsors
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Rajesh Narendran
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
\[C-11\]NOP-1A
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
\[A\] Alcohol use disorders (AUD) Inclusion Criteria: 1. Males or Females 2. Fulfill DSM5 diagnosis for alcohol use disorder 3. Medically Healthy
Exclusion criteria
1. Pregnancy or lactation 2. Comorbid severe/major medical, psychiatric (such as bipolar and psychotic disorders, etc.,) and current comorbid drug use disorders (other than tobacco use and recreational marijuana use) 3. Metal implants or paramagnetic objects contained within the body which may interfere with MRI scans 4. Currently employed as a radiation worker, or participation in radiation drug research procedures within the previous year 5. Currently on any psychotropic medications that can influence nociceptin transmission in the brain \[B\]Healthy controls Inclusion Criteria: 1. Males or females 2. Absence of present or past psychiatric conditions (including alcohol or drug use disorders) 3. Medically Healthy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| [C-11]NOP-1A VT | Baseline | VT-Volume of distribution expressed relative to total plasma |
Countries
United States
Outcome results
None listed