Microbiota
Conditions
Keywords
oral microbiota, 16S rRNA gene, Graves' disease, Methimazole, Propylthiouracil, Hashimoto's thyroiditis
Brief summary
Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbial disorders such as autoimmune thyroiditis However, there is no report on the relationship between oral microecology and autoimmune thyroiditis. Therefore, our group will study the correlation between oral microbiota and AITD.
Detailed description
Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbiological disorders. Intestinal microelements Both ecology and oral microecology belong to the category of microorganisms. It has been reported in the literature that intestinal microecology occurs disorder of autoimmune thyroiditis. However, there is no report on the correlation between oral microecology and autoimmune thyroiditis. When oral microbe flora When the immune system is disrupted, the immune balance is broken, the immune system is over-active, and the autoimmune disease (AID) is lost to the autoantigens and non-pathogenic commensal microbial flora antigens, including rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, inflammatory bowel disease, and allergic diseases. However, the association between oral microbial flora and AITD remains unclear. . Therefore, the research group will carry out the correlation between oral microbial flora and AITD.
Interventions
DRUGMethimazole Pill
Patients who developed GD received methimazole treatment
Patients who developed GD received propylthiouracil treatment
Sponsors
First Affiliated Hospital of Harbin Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged 18 to 65 years * GD was clinical diagnosed and thyroid function returned to normal * HT was clinical diagnosed and thyroid function is normal.
Exclusion criteria
* Pregnancy * Lactation * Cigarette smoking * Alcohol addiction * Hypertension * Diabetes mellitus * Lipid dysregulation * BMI \> 27 * Recent (\< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, laxatives, proton pump inhibitors, insulin sensitizers or Chinese herbal medicine * History of disease with an autoimmune component, such as MS, rheumatoid arthritis, IBS, or IBD * History of malignancy or any gastrointestinal tract surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Transcriptional changes in oral microbiota | Baseline, 3 months, 6 months, 9 months, 12 months | The microbiota measured by 16S rRNA gene |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum thyroid function changed | Baseline, 3 months, 6 months, 9 months, 12 months | Serum thyroid function measured by Immunohistochemistry |
Other
| Measure | Time frame | Description |
|---|---|---|
| Serum thyroid related antibodies changed | Baseline, 3 months, 6 months, 9 months, 12 months | Serum thyroid related antibodies measured by Immunohistochemistry |
Countries
China
Contacts
Primary ContactYunwei Wei
Outcome results
None listed