Visual Quality and Contrast Sensitivity Function for Limbal Dermoid Children After Corneal Transplantation

Zhongshan Ophthalmic Center, Sun Yat-Sen University,China

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03447041

Enrollment

Registered

2018-02-27

Start date

2018-03-01

Completion date

2020-12-30

Last updated

2021-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Limbal Dermoid

Keywords

Keratopathy, Visual Quality, Contrast Sensitivity Function

Brief summary

This study is to inquiry the contrast sensitivity function in the 50 eyes of limbal dermoid children with keratoplasty with quick contrast sensitivity function (quick CSF) test, as well asa to analyze its relationship between visual quality.

Detailed description

Limbal dermoid(LD) is a congenital benign tumor that consist of overgrowths of epidermal appendages that influence vision and cause visual abnormalities due to the induced corneal astigmatism. A large proportion of patients, all of whom had epibular dermoids, has amblyopia. In a previous study, keratoplasty, such as LKP (Lamellar Keratoplasty) or PKP (Penetrating Keratoplasty), was shown to facilitate the reconstruction of appearance, and improve visual acuity significantly postoperatively. However, the reestablishment of visual acuity and visual function are always ignored by parents after visual appearance recovery. Several studies have evaluated the visual acuity and objective and subjective visual function of patients after keratoplasty. These outcomes include contrast sensitivity (CS), refractive error, graft clarity, anterior and posterior corneal higher order aberration, and vision-related quality of life. Although a subjective visual function assessment has been deemed critical, postkeratoplasty patients with vision complaints are not uncommon despite clear grafts and relatively good visual acuity, and the visual function evaluation for LD were relatively less. 50 eyes of 50 limbal dermoid children with corneal transplantation more than 1 year were included in this study. All participants underwent an ophthalmic examination that included slit-lamp biomicroscopy, visual acuity, quick CSF under full optical correction, 9-SF life quality questionnaire and fundus examination. Then the normal group would be covered by the positive spherical lens of 1.0D to 6.0D to repress the BCVA to 0.1 to 0.9 respectively to compare the visual functions with the keratoplasty patients on the same visual acuity.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

7 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Accept the corneal transplantation based on the clinical diagnosis of ocular surface disease; * more than 7 and less than 60 years old; * absence of other ocular disorders and no history of eye surgery and other systemic diseases.

Exclusion criteria

* less than 7 or more than 60 years old; * with the history of eye surgery and other systemic diseases.

Design outcomes

Primary

Measure	Time frame	Description
The contrast sensitivity function tested by quick CSF in the keratoplasty group	on 1 year postkeratoplasty	The quick CSF (contrast sensitivity function) tests including AULCSF (the area under the log CSF) and Cutoff SF (Cutoff sensitivity function)

Countries

China

Outcome results