Premature Ventricular Contraction
Conditions
Keywords
premature, pvc
Brief summary
Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.
Detailed description
Premature ventricular complex is a very frequent arrhythmia. Suggested mechanisms for PVCs are reentry, triggered activity, and enhanced automaticity. Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Half-lives of catecholamines are very short and rather changeable. Therefore, 24 hours urine levels of catecholamines are the more sensitive than plasma levels. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.
Interventions
DIAGNOSTIC_TEST24 hours urine levels metanephrine and normetanephrine
24 hours rhythm recording and 24 hours urine measurement
Sponsors
TC Erciyes University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Inclusion criteria
* PVC's rate is more than % 5 in 24 hours rhythm recording
Exclusion criteria
* ischemic heart disease * hyperthyroidism * patients with low ejection fraction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| metanephrine and normetanephrine levels | about 10 months | metanephrine and normetanephrine levels asociated premature ventricular complex frequents |
Countries
Turkey (Türkiye)
Outcome results
None listed