Residence or Prolonged Visit at High Altitude as the Cause of Mountain Sickness
Conditions
Brief summary
This ambispective cohort study aims to evaluate the effect of high altitudes environment on human's physiological and metabolic markers, specific markers of main human systems, and incidence rate and severity of chronic mountain sickness (CMS).
Detailed description
Qinghai-Tibet plateau is a high altitudes area with average 3,000-5,000 meters height in China. As the partial pressure of oxygen in inspired air falls with increasing terrestrial elevation above sea level, many physiological variables in human body could be affected by this hypobaric hypoxic environment. Up to date, there are no large scale clinical trials assessing these changes in chinese population. The study here would like to provide the newest medical information on the changes of physiological variables and correlation between specific risk factors in chinese adults living at high altitudes for work purpose.
Interventions
OTHERChronic hypoxic environment
Chronic hypoxic environment. Since the partial pressure of oxygen in inspired air falls with increasing terrestrial elevation above sea level, many physiological variables in adults would be affected by the chronic hypoxia environment.
Sponsors
Beijing University of Chinese Medicine
Chengdu University of Traditional Chinese Medicine
Tibetan Traditional Medical College
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Be provided verbal or written informed consent; * Men and women ≥ 30 and ≤ 65 years of age; * Adults living at Qinghai-Tibet Plateau for Work Purpose, and the altitude of residence is more than 2,500 meters; * Providing electronical or paper medical examination reports which conducted in 2016.
Exclusion criteria
* Pregnant or breast-feeding women; * Be excluded by Principal investigator for subject's compliance or safety reasons.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in blood pressure as measured by sphygmomanometer from baseline at first year | Baseline and 1st year | The blood pressure will be described in the format of diastolic pressure/systolic pressure, and the unit of measure is mmHg. |
| Change in blood glucose from baseline at first year | Baseline and 1st year | — |
| Change in serum lipid from baseline at first year | Baseline and 1st year | — |
| Change in weight from baseline at first year | Baseline and 1st year | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in blood pressure as measured by sphygmomanometer from baseline at third year | Baseline and 3rd year | The blood pressure will be described in the format of diastolic pressure/systolic pressure, and the unit of measure is mmHg. |
| Change in serum lipid from baseline at second year | Baseline and 2nd year | — |
| Change in serum lipid from baseline at third year | Baseline and 3rd year | — |
| Change in blood glucose from baseline at third year | Baseline and 3rd year | — |
| Pathological changes from baseline at first year in human body systems | Baseline and 1st year | — |
| Pathological changes from baseline at second year in human body systems | Baseline and 2nd year | — |
| Pathological changes from baseline at third year in human body systems | Baseline and 3rd year | — |
| The incidence rate and severity of chronic mountain sickness (CMS) | The 2nd year | The diagnosis and severity of CMS is identified and assessed using The Qinghai Chronic Mountain Sickness Score. The score ranges from 0 to 27, and a higher value means a worse outcome. |
| Change in blood glucose from baseline at second year | Baseline and 2nd year | — |
| Change in weight from baseline at second year | Baseline and 2nd year | — |
| Change in weight from baseline at third year | Baseline and 3rd year | — |
| Change in blood pressure as measured by sphygmomanometer from baseline at second year | Baseline and 2nd year | The blood pressure will be described in the format of diastolic pressure/systolic pressure, and the unit of measure is mmHg. |
Other
| Measure | Time frame |
|---|---|
| Relationship between altitudes and pathological changes in human body under chronic hypoxic environment | Up to the 3rd year |
| Relationship between gender and pathological changes in human body under chronic hypoxic environment | Up to the 3rd year |
| Relationship between age and pathological changes in human body under chronic hypoxic environment | Up to the 3rd year |
Countries
China
Contacts
Primary ContactTonghua Liu, Professor
Backup ContactYingchun He, Master
Outcome results
None listed