Selenium Deficiency
Conditions
Brief summary
Previous literature has found potential association between selenium deficiency and inactivated glutathione peroxidase and deiodinase, which may contribute to subsequent elevation of T4 and ratio of T4/T3. Conduction of a case-control study (ID: Liuyanping3) has been applied on Clinicaltrials.gov to further elucidate effect of selenium deficiency on thyroid function. Based on its data, the investigators will perform a randomized, placebo-controlled,single-blinded crossover study on 20 participants with selenium deficiency to verify health consequence of selenium.
Interventions
DIETARY_SUPPLEMENTselenium supplementation
administration of selenium-rich corn powder 20g/d offering selenium 100μg/d
DIETARY_SUPPLEMENTordinary corn powder
ordinary corn powder,20g/d(selenium contain \<0.5ug/20g).
Sponsors
Peking Union Medical College Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Masking description
All participants will be blinded. Both the selenium-rich corn powder and the ordinary corn powder (placebo) have the same smell, color and taste.
Intervention model description
20 participants with selenium deficiency (confirmed in previous phase (ID: Liuyanping3)) will be recruited to receive selenium-rich corn powder (20g/d, offering selenium 100μg/d) and ordinary corn powder (20g/d, offering selenium \< 0.5μg/d ) in two different sequences (10 subjects each) with a four-week washout period.Plasma samples were obtained at different time points before and after administration of the selenium-rich corn powder and ordinary corn powder.
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of selenium deficiency through serum selenium test in previous phase (ID: Liuyanping3) of the study * Should have stable body weight in the latest 3 months; * Should be not prescribed with thyroid hormone replacement therapy * Should be without medical history of thyroid surgery or iodine radiotherapy * Should have normal FT3, FT4 and TSH.
Exclusion criteria
* Clinical diagnosis of acute critical illness in the latest 1 year * Have had weight fluctuation by more than 5% * Eating disorders * Neuropsychological disorders * Allergy to corn or yeast
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| comparison of thyroid function | plasma sample will be collected at -1w/4w/8w/12w | comparison of thyroid function between administration of selenium supplementation and placebo |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| comparison of serum selenium | plasma sample will be collected at -1w/4w/8w/12w | comparison of serum selenium between administration of selenium supplementation and placebo |
| comparison of erythrocyte glutathione peroxidase activity | plasma sample will be collected at -1w/4w/8w/12w | comparison of erythrocyte glutathione peroxidase activity between administration of selenium supplementation and placebo |
| comparison of serum deiodinase activity | plasma sample will be collected at -1w/4w/8w/12w | comparison of serum deiodinase activity between administration of selenium supplementation and placebo |
Contacts
Primary ContactYanping Liu
Outcome results
None listed