CPAP for OSA on Myocardial Salvage After pPCI for STEMI Patients

Effect of Continuous Positive Airway Pressure (CPAP) for Obstructive Sleep Apnea (OSA) on Myocardial Salvage After Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction: A Prospective, Multicenter, Randomized Controlled Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03444857

Enrollment

120

Registered

2018-02-23

Start date

2018-03-26

Completion date

2019-06-30

Last updated

2018-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea, ST Elevation Myocardial Infarction

Keywords

Continuous Positive Airway Pressure, Myocardial Salvage, Obstructive Sleep Apnea, ST Elevation Myocardial Infarction

Brief summary

The aim of this randomized controlled trial to investigate the effects of CPAP treatment on myocardial salvage index and clinical outcomes at 3 months in patients with OSA and ST-Segment Elevation Myocardial Infarction (STEMI) after primary percutaneous coronary intervention (PPCI).

Interventions

DEVICEContinuous positive airway pressure

The optimal continuous positive airway pressure (CPAP, AutoSet S9, ResMed, Sydney, Australia) settings will be determined during 1-2 nights within 7 days after pPCI.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. 18 to 80 years old 2. First-time STEMI 3. Successful PPCI (≥1 coronary artery) within 24h after symptom onset 4. Moderate to severe OSA (AHI≥15) 5. Written informed consent

Exclusion criteria

1. Prior myocardial infarction 2. Prior myocardial revascularization (PCI or CABG) 3. Cardiogenic shock (mean arterial pressure \<60mmHg), severe heart failure (Killip≥3) 4. LM or multivessel disease indicated for CABG 5. History of stroke 6. Severe insomnia, chronic sleep deprivation, abnormal circadian rhythm (sleep \<4h/night) 7. Severe COPD: FEV1/FVC \<70% or FEV1 \<50% predicted value (within 4 weeks) 8. Predominantly central sleep apnea (≥25% central events or central AHI ≥10/h) 9. Previous or current use of CPAP 10. Severe comorbidities: eg. malignancy (life expectancy \<2 years) 11. Known or planned pregnancy 12. Known contraindication to CMR 13. Patients with contraindication to CPAP or who cannot tolerate it 14. Participation in other clinical trial in recent 3 months 15. Any condition that in the opinion of investigator that may jeopardize patient compliance, eg. significant memory, perceptual, or behavioral disorder, depression, severe alcohol consumption, or a history of noncompliance

Design outcomes

Primary

Measure	Time frame	Description
Myocardial salvage index	3 months	To investigate the effects of CPAP treatment on myocardial salvage index (MSI, assessed by cardiovascular magnetic resonance imaging, CMR) at 3 months in patients with OSA and ST-Segment Elevation Myocardial Infarction (STEMI) after primary percutaneous coronary intervention (PPCI)

Countries

China

Contacts

Primary ContactShao-Ping NIE, MD

spnie@126.com86 13701186772

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026