Supratentorial Tumors
Conditions
Keywords
brain relaxation, mannitol, supratentorial tumours
Brief summary
Although mannitol is used for brain relaxation during neurosurgery and in the treatment of raised intracranial pressure; there is not a consensus on its safe, effective dose and the duration of its administration. This study aimed to compare the effects of the mannitol in different use times, on the brain relaxation, electrolyte, lactate levels of the blood, peroperative fluid balance and the volume of the urine in supratentorial mass resection surgeries.
Interventions
DRUGMannitol
This drug is in our routine use of neuroanesthesia, are given for facilitate brain relaxation
Sponsors
Huashan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Intracranial shift \>3mm * Scheduled for supratentorial mass resection under elective conditions
Exclusion criteria
* Decompensated heart failure * kidney insufficiency * Diabetes insipidus, * Electrolyte imbalance and * Who are unconscious
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| brain relaxation score | just before dural opening | difference in brain relaxation after drug administration The assessment was performed using a 4-point scale, 1 denoting bulging or the condition that additional methods for brain relaxation are immediately and always required in order to continue the surgical procedure because of brain swelling; 2, firm or the condition that additional methods for brain relaxation are occasionally required to continue the surgical procedure; 3, adequate; 4, perfectly relaxed. In all patients, the degree of brain relaxation was assessed at the time of dural opening and satisfactory brain relaxation was defined as a brain relaxation score of 3 or 4. All the Secondary Outcome Measures below are observed the safety for intraoperative brain debulking during elective supratentorial craniotomy |
Secondary
| Measure | Time frame |
|---|---|
| Blood sodium levels | change in 30 minute intervals in the first 2 hour after study drug administration |
| Blood potassium levels | change in 30 minute intervals in the first 2 hour after study drug administration |
| Blood chlorine levels | change in 30 minute intervals in the first 2 hour after study drug administration |
| Blood lactate levels | change in 30 minute intervals in the first 2 hour after study drug administration |
| Fluid balance during operation | change in 30 minute intervals in the first 2 hour after study drug administration |
Countries
China
Outcome results
None listed