Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus

Evaluation of Long-Term Effects of Diode Laser Application on Periodontal Healing, Serum C-Reactive Protein and HbA1c Levels in Periodontal Treatment of Uncontrolled Type-2 Diabetic Subjects With Chronic Periodontitis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03444363

Enrollment

Registered

2018-02-23

Start date

2013-09-20

Completion date

2014-12-23

Last updated

2018-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Periodontal Disease

Keywords

laser, periodontal treatment, systemic inflammation, glycemic control

Brief summary

This study aimed to investigate the effects of diode laser (DL) in addition to non-surgical periodontal treatment on periodontal parameters, systemic inflammatory response, and serum hemoglobin A1c (HbA1c) level in patients with uncontrolled type 2 diabetes mellitus (T2DM) and chronic periodontitis.

Detailed description

This study was designed as a randomized, controlled, full-mouth, 6-month clinical trial. 37 patients (20 women and 17 men) with uncontrolled T2DM and chronic periodontitis who were selected from among those admitting to Dentistry Faculty of Inonu University and Turgut Ozal Medical Center completed this study. The patients were divided into two groups. The individuals in the control group underwent placebo laser treatment in addition to scaling and root planing (SRP). The individuals in the study group underwent DL (1 W power) in addition to SRP. Clinical index measurements were performed before treatment (T0), 3 months after treatment (T1), and 6 months after treatment (T2). Plaque index (PI), gingival index (GI), bleeding on probing (BOP), clinical attachment level (CAL), and probing depth (PD) were measured to determine periodontal status. HbA1c and C-reactive protein (CRP) levels were also analyzed using blood samples.

Interventions

DEVICELaser group

Laser application in addition to SRP

DEVICEControl group

Placebo laser application in addition to SRP

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Masking description

The results of the study were evaluated in a blinded manner

Intervention model description

This study was designed as a randomized, controlled.

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Having a diagnosis of type-2 DM according to the ADA criteria for at least two years before the study, HbA1c⩾7%,28 * Having no change in antidiabetic drugs in the last 3 months, * Having no major diabetes complications (because chronic complications of diabetes complicate metabolic control), * Presence of generalized CP,29 * Presence of an area with a pocket depth of 4-7 mm in at least four teeth in the upper jaw, * Presence of at least 20 teeth in the mouth, * Having no any systemic illness except for DM, * Having no smoke, * Receiving no periodontal treatment in the last 12 months, * Receiving no antibiotics or anti-inflammatory drugs for a long period in the last 6 months, * Not being pregnant or not to breastfeed, * Having no third molars.

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Laboratory findings	Six months	Serum HbA1c levels were measured using the high-performance liquid chromatography method.

Secondary

Measure	Time frame	Description
Clinical findings	Six months	Probing depth (PD) was measured the distance between the gingival margin and the deepest aspect of the pocket (mm).

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026