Aortic Valve Disease, Aortic Valve Stenosis, Atrial Fibrillation, Cardiac Arrythmias, Cardiac Surgery, Cardiac Tumor, Coronary Artery Disease, Mitral Valve Disease
Conditions
Keywords
Atrial fibrillation, Aortic stenosis, Coronary artery disease, Cardiac surgery, Atrial appendage
Brief summary
The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.
Detailed description
The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating cytokine profiles, purinergic signaling and atrial cardiomyopathy findings in tissue samples.
Interventions
PROCEDURECardiac surgery
Open heart surgery
Sponsors
Brigham and Women's Hospital
University of Turku
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Any open-heart cardiac surgery * Written informed consent * All-comers design
Exclusion criteria
* No informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Atrial fibrillation | postoperatively until 5 years follow-up | Occurrence of atrial fibrillation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial infarction | postoperatively until 5 years follow-up | Occurrence of Myocardial infarction |
| Transient ischemic attack | postoperatively until 5 years follow-up | Occurrence of Transient ischemic attack |
| Stroke | postoperatively until 5 years follow-up | Occurrence of stroke |
| Target vessel revascularization | postoperatively until 5 years follow-up | Occurrence of Target vessel revascularization |
| All-cause Mortality | postoperatively until 5 years follow-up | All-cause Mortality |
| Post-pericardiotomy syndrome | postoperatively until 1 years follow-up | Occurrence of Post-pericardiotomy syndrome |
Countries
Finland
Outcome results
None listed