Coronary Heart Disease, Healthy Control
Conditions
Keywords
aerobic exercise training, periodization, cerebral oxygenation and perfusion, cognition
Brief summary
The research project includes two components that assess exercise physiology parameters, cerebrovascular reserve, cognitive functions and cardiac function in coronary heart disease patients at rest, during an acute exercise, and after two different periodized training programs.
Interventions
OTHERExercise training
Patients will undergo three weekly exercise training sessions with periodized high-intensity interval training and resistance training for a period of 12 weeks.
Sponsors
Montreal Heart Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for patients with coronary heart disease: * Major * Adequate physical and mental capacities * Autonomy in daily activities * Documented coronary artery disease * Stable or recent coronary artery disease
Exclusion criteria
for patients with coronary heart disease: * Inability to complete the consent form * Acute coronary syndrome \< 3 months * Heart failure * Ejection fraction of the left ventricle \<40% * Coronary artery disease non revascularisable including left main coronary stenosis * Waiting for a bridging of the coronary artery * Chronic atrial fibrillation * Malignant arrhythmias during exercise * Restriction to non cardiopulmonary exercise * Severe intolerance to exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal oxygen uptake (VO2peak) with gas exchange | At baseline and following 12 weeks exercise training intervention | VO2peak will be measured during maximal exercise test with a gas exchange device. The highest value reached during the exercise phase of the maximal test (ergocycle) will be considered as the VO2peak. We will measure change of VO2peak before and after exercise training. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral hemodynamics | At baseline and following 12 weeks exercise training intervention | Cerebral hemodynamics will be measured using near-infrared spectroscopy (NIRS) system during maximal and submaximal exercise tests. We will measure change of cerebral hemodynamics before and after exercise training |
| Cognitive functions at rest by a by standard pen-paper battery test | At baseline and following 12 weeks exercise training intervention | Cognitive functions will be measured at rest with a pen-paper battery test by a neuropsychologist. We will measure change of score to the cognitive tests before and after exercise training. |
| Cardiac hemodynamics | At baseline and following 12 weeks exercise training intervention | Cardiac hemodynamics will be measured continuously during the maximal exercise test on bike using an impedance cardiography device. We will measure change of cardiac hemodynamics before and after exercise training. |
| Standard echocardiographic parameter of left and right ventricular strain | At baseline and following 12 weeks exercise training intervention | global longitudinal strain (%) will be measued at rest for both ventricule |
Countries
Canada
Outcome results
None listed