Chlorhexidine, Ventilator Associated Pneumonia
Conditions
Keywords
Chlorhexidine, Gram-negative, Colonization
Brief summary
This study will assess the utility of different chlorhexidine mouthwash concentrations on ICU patients to decolonize their oral cavities from gram-negative bacteria, since this is a non-desirable condition that leads to higher mortality rates and longer hospitalization times. One group will receive the 0.12% chlorhexidine mouthwash and the other group will receive the 2% chlorhexidine mouthwash.
Interventions
DRUGChlorhexidine gluconate at 2%
Mouth Rinse with Chlorhexidine gluconate at 2% every 12 hours, one week.
DRUGChlorhexidine gluconate at 0.12%
Mouth Rinse with Chlorhexidine gluconate at 0.12% every 12 hours, one week.
Sponsors
Universidad de Guanajuato
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with minimum required age of consent that were admitted to the intensive care unit and who received at least 48 hours of mechanical ventilation.
Exclusion criteria
* Patients who wish to withdraw consent and leave the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gram-negative decolonization rate | 2 weeks | Patients admitted to the ICU who were originally colonized with gram-negative bacteria and at the end of the study are no longer colonized by gram-negative bacteria. |
| Gram-negative colonization rate | 2 weeks | Patients admitted to the ICU who were originally not colonized with gram-negative bacteria and at the end of the study are colonized by gram-negative bacteria. |
Countries
Mexico
Contacts
Primary ContactJosé A Álvarez, PhD
Backup ContactMarco A López, MD
Outcome results
None listed