Aspirin-Sensitive Asthma With Nasal Polyps, Samter's Syndrome
Conditions
Keywords
alcohol sensitivity, red wine, aerd
Brief summary
The purpose of this study is to determine what type of reactions in the body may be responsible for the respiratory symptoms that occur when patients with Aspirin Exacerbated Respiratory Disease (AERD) drink alcoholic beverages. These reactions are most often seen with red wine.
Detailed description
This is a prospective trial of approximately 60 subjects with AERD to explore the mechanisms behind the physiologic reactions that occur when drinking alcoholic beverages. At various time points patients will be asked to ingest a variety of substances found in red wine after which blood and urine markers of the reaction will be measured.
Interventions
DIETARY_SUPPLEMENTWater
Serum and urine markers will be obtained after drinking 5 oz of water
DIETARY_SUPPLEMENTRed wine
Serum and urine markers will be obtained after drinking 5 oz of water
DIETARY_SUPPLEMENTPolyphenolic Compounds
Serum and urine markers will be obtained after consuming 100 mg of provinols powder
Sponsors
University of Virginia
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy Controls - must be 21 years or older * Aspirin Tolerant Asthma and AERD arms must note a sensitivity to alcoholic beverages
Exclusion criteria
* Enzymopathies * Mastocytosis * Alcoholism * Prior severe respiratory reaction to alcohol consumption * Current pregnancy * Monoamine Oxidase Inhibitor (MAOI) use * Age under 21 * Use of leukotriene modifier 1 week before study intervention * Having undergone and maintained aspirin desensitization
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 24 Hour Urinary Leukotriene-E4 (LTE4) | 24 hour | Urine LTE4 ng/mg Cr |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 24 Hour Urinary Prostaglandin-D2 (PGD2) metabolite | 24 hour collection | Urine PGD2 metabolite ng/mg Cr |
| Whole blood Activated Basophil Level | 2 hours after ingestion | Proportion of activated basophils in whole blood after ingestion |
| Whole Blood Activated Eosinophil Level | 2 hours after ingestion | Proportion of activated eosinophils in whole blood after ingestion |
| Whole Blood tryptase | 2 hours after ingestion | Level of tryptase concentration in whole blood |
Countries
United States
Contacts
Primary ContactBJ Ferrebee-Ghamandi, MHA
Outcome results
None listed