Maternal Serum Homocysteine Levels and Uterine Artery Pulsatility Indices in Preterm Labor

Maternal Serum Homocysteine Levels and Uterine Artery Pulsatility Index as Predictors of Spontaneous Preterm Labor

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03440281

Enrollment

200

Registered

2018-02-22

Start date

2015-08-01

Completion date

2017-11-01

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm Labor

Brief summary

Study included all pregnant women admitted with threatened preterm labor during the study period. All participants underwent estimation of maternal serum homocysteine level and assessment of uterine artery Doppler indices.

Detailed description

Prospective cohort study. Study approval by local ethics committee. Informed written consent. Study included all pregnant women admitted with threatened preterm labor during the study period. All participants underwent estimation of maternal serum homocysteine level and assessment of uterine artery Doppler indices.

Interventions

DIAGNOSTIC_TESTUterine artery doppler

Uterine artery Doppler pulsatility indices

DIAGNOSTIC_TESTMaternal serum homocysteine estimation

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Inclusion criteria

* Singleton pregnancy * More than 28 and less than 35 gestational weeks. * Threatened preterm labor

Exclusion criteria

* Medical disorders complicating pregnancy * Obstetric conditions complicating pregnancy (e.g., placenta previa, multiple gestation,PPROM, ....etc) * Fetal anomalies or distress

Design outcomes

Primary

Measure	Time frame	Description
The accuracy of serum homocysteine levels and uterine artery pulsatility indices (UtA-PI ) for prediction of preterm labor	Single measurement at the end of the study ( around 37 gestational weeks)	Sensitivity (%), specificity (%), positive predictive value (%), negative predictive value (%), positive likelihood ratio (number), negative likelihood ratio (number), accuracy (%) of serum homocysteine and UtA-PI for prediction of preterm labor

Secondary

Measure	Time frame	Description
Gestational age at delivery	Single measurement at the end of the study ( around 37 gestational weeks)	Gestational age at delivery (Weeks),
Demographic and clinical characteristics of the study groups	Single measurement on the day one of hospital admission between 28-35 gestational weeks	Maternal age (year), Body mass index (kilogram per squared meter), Gestational age at admission (Weeks), Maternal serum Homocysteine level ( micromoles/liter), uterine artery pulsatility index ( number)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026